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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1994-2-14
|
| pubmed:abstractText |
The value of measuring the urinary concentration of alpha 2-macroglobulin in addition to that of C-reactive protein (CRP) was assessed in a prospective study of 78 consecutive patients (29 women, 49 men; mean age 48.7 [19-75] years) after renal transplantation. alpha 2-Macroglobulin was never demonstrated in urine when the course was normal (n = 38), cytomegalovirus infection had occurred (n = 26) or acute cyclosporin nephrotoxicity (n = 5) or glomerular disease in the transplant (n = 10). CRP was present in only a few such cases. Interstitial rejections (n = 26) always led to urinary alpha 2-macroglobulin and CRP excretion without haematuria, while in vascular rejection (n = 3) the haemoglobin test was also positive. Urinary infection (n = 20) and urosepticaemia (n = 6) always brought about the urinary excretion of alpha 2-macroglobulin and CRP, as well as a usually highly positive haemoglobin test. alpha 2-Macroglobulin was absent but CRP always present in extrarenal bacterial infections (n = 30). Postrenal blood admixture was always characterized by a positive haemoglobin test and alpha 2-macroglobulin in urine, while in most cases (83%) CRP was absent. --These results indicate that the constellation "alpha 2-macroglobulin negative/CRP positive" is a pathognomonic for extrarenal bacterial infection (sensitivity 100%, specificity 98.9%). The presence of alpha 2-macroglobulin alone makes postrenal blood admixture probable. If both proteins are present in the urine, rejection and urogenital bacterial infection must be excluded by further tests.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0012-0472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7506645-Adult,
pubmed-meshheading:7506645-Aged,
pubmed-meshheading:7506645-Bacterial Infections,
pubmed-meshheading:7506645-C-Reactive Protein,
pubmed-meshheading:7506645-Cyclosporine,
pubmed-meshheading:7506645-Cytomegalovirus Infections,
pubmed-meshheading:7506645-Diagnosis, Differential,
pubmed-meshheading:7506645-Female,
pubmed-meshheading:7506645-Graft Rejection,
pubmed-meshheading:7506645-Hematuria,
pubmed-meshheading:7506645-Hemoglobinuria,
pubmed-meshheading:7506645-Humans,
pubmed-meshheading:7506645-Kidney,
pubmed-meshheading:7506645-Kidney Diseases,
pubmed-meshheading:7506645-Kidney Transplantation,
pubmed-meshheading:7506645-Male,
pubmed-meshheading:7506645-Middle Aged,
pubmed-meshheading:7506645-Prospective Studies,
pubmed-meshheading:7506645-Sepsis,
pubmed-meshheading:7506645-Urinary Tract Infections,
pubmed-meshheading:7506645-alpha-Macroglobulins
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
[alpha 2-macroglobulin in urine. Significance for differential diagnosis of rejection and infections after kidney transplantation].
|
| pubmed:affiliation |
Klinik für Innere Medizin, Medizinischen Universität Lübeck.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|