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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0039635,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C0205178,
umls-concept:C0243045,
umls-concept:C0332157,
umls-concept:C0591833,
umls-concept:C1274040,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1994-2-10
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pubmed:abstractText |
An increase in tyrosine phosphorylation of two hepatic S9 proteins migrating at 34 and 33 kDa that cross-reacted with anti-PSTAIR antibody on immunoblots was seen 24 h after administration of a single dose of 0.25, 0.5, 1 or 2 micrograms 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg to C57BL/6J female mice. Two hepatic S9 proteins migrating at 34 and 33 kDa that cross-reacted with anti-cdc2 C-terminus antibody on immunoblots were observed in corn oil control mice; increased expression of these proteins was seen with increasing doses of TCDD. A maximal increase in expression of 3-times the control was observed at 1 and 2 micrograms TCDD/kg for both p34 and p33. The stimulation of enhanced tyrosylphosphorylation and expression of cyclin dependent kinases p34cdc2 and p3cdk2 by TCDD is consistent with a mechanism of action of TCDD toxicity associated with stimulation of cellular proliferation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/CDC2-CDC28 Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrachlorodibenzodioxin,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
197
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1070-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7506535-Animals,
pubmed-meshheading:7506535-Antibodies, Monoclonal,
pubmed-meshheading:7506535-CDC2 Protein Kinase,
pubmed-meshheading:7506535-CDC2-CDC28 Kinases,
pubmed-meshheading:7506535-Cyclin-Dependent Kinase 2,
pubmed-meshheading:7506535-Cyclin-Dependent Kinases,
pubmed-meshheading:7506535-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7506535-Female,
pubmed-meshheading:7506535-Gene Expression,
pubmed-meshheading:7506535-Immunoblotting,
pubmed-meshheading:7506535-Liver,
pubmed-meshheading:7506535-Mice,
pubmed-meshheading:7506535-Mice, Inbred C57BL,
pubmed-meshheading:7506535-Phosphoproteins,
pubmed-meshheading:7506535-Phosphotyrosine,
pubmed-meshheading:7506535-Protein Kinases,
pubmed-meshheading:7506535-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7506535-Reference Values,
pubmed-meshheading:7506535-Tetrachlorodibenzodioxin,
pubmed-meshheading:7506535-Tyrosine
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pubmed:year |
1993
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pubmed:articleTitle |
Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation and expression of murine hepatic cyclin dependent kinases.
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pubmed:affiliation |
Section of Cellular Physiology, Paracelsian, Inc., 222 Langmuir Laboratories, Cornell Technology Park, Ithaca, NY 14850.
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pubmed:publicationType |
Journal Article
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