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rdf:type |
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lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0012888,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0035379,
umls-concept:C0037791,
umls-concept:C0220806,
umls-concept:C0243072,
umls-concept:C0392747,
umls-concept:C0442805,
umls-concept:C1524059,
umls-concept:C1554963
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pubmed:issue |
2-3
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|
pubmed:dateCreated |
1994-2-10
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pubmed:abstractText |
The reverse transcriptase (RT) inhibition and the specificity of 15 aminonaphthalenesulfonic acid derivatives were examined with RT of a simian immunodeficiency virus derived from an African green monkey (SIVagmTYO-7). The two compounds with the strongest RT inhibition (NF415) or the highest specificity (NF345), together with suramin, were evaluated against polymerase alpha-primase complex from calf thymus. We have also compared the kinetics of inhibition of the viral and the cellular polymerase by these three compounds. While RT inhibition followed a mixed competitive and non-competitive mechanism, inhibition of the DNA polymerase alpha was competitive for suramin and non-competitive for NF415 and NF345. Certain structural characteristics appeared to be common for specific RT inhibitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0166-3542
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-19
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7506509-Animals,
pubmed-meshheading:7506509-Biological Transport,
pubmed-meshheading:7506509-Cells, Cultured,
pubmed-meshheading:7506509-Cercopithecus aethiops,
pubmed-meshheading:7506509-DNA Polymerase II,
pubmed-meshheading:7506509-DNA Primase,
pubmed-meshheading:7506509-Dose-Response Relationship, Drug,
pubmed-meshheading:7506509-Humans,
pubmed-meshheading:7506509-Kinetics,
pubmed-meshheading:7506509-Naphthalenesulfonates,
pubmed-meshheading:7506509-Permeability,
pubmed-meshheading:7506509-RNA Nucleotidyltransferases,
pubmed-meshheading:7506509-RNA-Directed DNA Polymerase,
pubmed-meshheading:7506509-Reverse Transcriptase Inhibitors,
pubmed-meshheading:7506509-Simian immunodeficiency virus,
pubmed-meshheading:7506509-Structure-Activity Relationship,
pubmed-meshheading:7506509-Suramin
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pubmed:year |
1993
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pubmed:articleTitle |
Chemical modifications of aminonaphthalenesulfonic acid derivatives increase effectivity and specificity of reverse transcriptase inhibition and change mode of action of reverse transcriptase and DNA polymerase alpha inhibition.
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pubmed:affiliation |
German Primate Centre, Department of Virology and Immunology, Göttingen.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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