| pubmed-article:7506471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0026131 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0037657 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C2828358 | lld:lifeskim |
| pubmed-article:7506471 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:7506471 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7506471 | pubmed:dateCreated | 1994-2-4 | lld:pubmed |
| pubmed-article:7506471 | pubmed:abstractText | We performed a double-blind randomized placebo-controlled trial of recombinant human growth hormone (hGH) in normally lactating women (N = 8 per group) to investigate the endocrine mode of action of the galactopoietic effect of this hormone. Insulin-like growth factors I (IGF-I) and II (IGF-II) and their binding proteins (IGFBP-1, IGFBP-2 and IGFBP-3) were measured by radioimmunoassay in plasma and milk samples collected throughout the study. All assays were validated for human plasma and milk. Human GH treatment (0.1 IU.kg-1 body wt.day-1 for 7 days) increased plasma concentrations of IGF-I from 22.1 +/- 1.3 nmol/l (mean +/- SEM) to 59.7 +/- 2.5 nmol/l (p < 0.01). At the end of the study the increase in plasma IGF-I correlated significantly with the increase in milk volume (r = 0.67, p < 0.005, N = 16). The IGF-I levels were considerably lower in milk, with 0.14 +/- 0.03 nmol/l before and 0.31 +/- 0.04 nmol/l after hGH treatment. The increase in milk IGF-I levels (134.0 +/- 14.5%) with hGH treatment was significant (p < 0.01) and plasma and milk IGF-I concentrations correlated significantly when considering all samples of the study (r = 0.45, p < 0.001, N = 56). The concentrations of IGF-II were not changed significantly with hGH treatment in plasma (52.5 +/- 2.5 nmol/l before and 42.6 +/- 3.9 nmol/l after treatment) or milk (2.1 +/- 0.29 nmol/l before and 2.3 +/- 0.49 nmol/l after hGH treatment).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7506471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7506471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7506471 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7506471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7506471 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7506471 | pubmed:issn | 0001-5598 | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:GluckmanP DPD | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:BlumW FWF | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:BreierB HBH | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:GallaherB WBW | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:SchwanderJJ | lld:pubmed |
| pubmed-article:7506471 | pubmed:author | pubmed-author:MilsomS RSR | lld:pubmed |
| pubmed-article:7506471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7506471 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:7506471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7506471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7506471 | pubmed:pagination | 427-35 | lld:pubmed |
| pubmed-article:7506471 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:7506471 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7506471 | pubmed:articleTitle | Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women. | lld:pubmed |
| pubmed-article:7506471 | pubmed:affiliation | Department of Paediatrics, University of Auckland, New Zealand. | lld:pubmed |
| pubmed-article:7506471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7506471 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7506471 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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