Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-2-4
|
| pubmed:abstractText |
We performed a double-blind randomized placebo-controlled trial of recombinant human growth hormone (hGH) in normally lactating women (N = 8 per group) to investigate the endocrine mode of action of the galactopoietic effect of this hormone. Insulin-like growth factors I (IGF-I) and II (IGF-II) and their binding proteins (IGFBP-1, IGFBP-2 and IGFBP-3) were measured by radioimmunoassay in plasma and milk samples collected throughout the study. All assays were validated for human plasma and milk. Human GH treatment (0.1 IU.kg-1 body wt.day-1 for 7 days) increased plasma concentrations of IGF-I from 22.1 +/- 1.3 nmol/l (mean +/- SEM) to 59.7 +/- 2.5 nmol/l (p < 0.01). At the end of the study the increase in plasma IGF-I correlated significantly with the increase in milk volume (r = 0.67, p < 0.005, N = 16). The IGF-I levels were considerably lower in milk, with 0.14 +/- 0.03 nmol/l before and 0.31 +/- 0.04 nmol/l after hGH treatment. The increase in milk IGF-I levels (134.0 +/- 14.5%) with hGH treatment was significant (p < 0.01) and plasma and milk IGF-I concentrations correlated significantly when considering all samples of the study (r = 0.45, p < 0.001, N = 56). The concentrations of IGF-II were not changed significantly with hGH treatment in plasma (52.5 +/- 2.5 nmol/l before and 42.6 +/- 3.9 nmol/l after treatment) or milk (2.1 +/- 0.29 nmol/l before and 2.3 +/- 0.49 nmol/l after hGH treatment).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Somatomedins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0001-5598
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
129
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
427-35
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7506471-Adult,
pubmed-meshheading:7506471-Analysis of Variance,
pubmed-meshheading:7506471-Blotting, Western,
pubmed-meshheading:7506471-Breast,
pubmed-meshheading:7506471-Carrier Proteins,
pubmed-meshheading:7506471-Double-Blind Method,
pubmed-meshheading:7506471-Female,
pubmed-meshheading:7506471-Growth Hormone,
pubmed-meshheading:7506471-Humans,
pubmed-meshheading:7506471-Insulin-Like Growth Factor Binding Protein 1,
pubmed-meshheading:7506471-Insulin-Like Growth Factor Binding Protein 2,
pubmed-meshheading:7506471-Insulin-Like Growth Factor I,
pubmed-meshheading:7506471-Insulin-Like Growth Factor II,
pubmed-meshheading:7506471-Lactation,
pubmed-meshheading:7506471-Milk, Human,
pubmed-meshheading:7506471-Radioimmunoassay,
pubmed-meshheading:7506471-Recombinant Proteins,
pubmed-meshheading:7506471-Regression Analysis,
pubmed-meshheading:7506471-Somatomedins,
pubmed-meshheading:7506471-Time Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women.
|
| pubmed:affiliation |
Department of Paediatrics, University of Auckland, New Zealand.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|