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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1994-1-19
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pubmed:databankReference |
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pubmed:abstractText |
A form of G-->A hypermutation preferentially affecting GA dinucleotides of genomic RNA has been found to occur in retroviral systems ("type 1"). In a detailed longitudinal study of an AIDS patient we have observed a new type of G-->A hypermutation, which preferentially affects one or more 5' G residues in runs of G's. HIV-1 proviral DNA samples obtained at widely separate times during this patient's course contained representatives of this type of G-->A hypermutation, designated "type 2." We propose that G-->A hypermutation is caused by a mutated form of the HIV-1 reverse transcriptase; and that hypermutated DNA may persist for long periods in infected patients, perhaps as proviral DNA in long-lived cell lineages. Like type 1 G-->A hypermutation, type 2 G-->A hypermutation may contribute to the heterogeneity of replicating pools of HIV by recombination.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0889-2229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:geneSymbol |
pol
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7504935-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7504935-Amino Acid Sequence,
pubmed-meshheading:7504935-Base Sequence,
pubmed-meshheading:7504935-Consensus Sequence,
pubmed-meshheading:7504935-DNA, Viral,
pubmed-meshheading:7504935-DNA Mutational Analysis,
pubmed-meshheading:7504935-Follow-Up Studies,
pubmed-meshheading:7504935-Genes, pol,
pubmed-meshheading:7504935-HIV Reverse Transcriptase,
pubmed-meshheading:7504935-HIV-1,
pubmed-meshheading:7504935-Humans,
pubmed-meshheading:7504935-Leukocytes, Mononuclear,
pubmed-meshheading:7504935-Molecular Sequence Data,
pubmed-meshheading:7504935-Mutation,
pubmed-meshheading:7504935-Proviruses,
pubmed-meshheading:7504935-RNA-Directed DNA Polymerase,
pubmed-meshheading:7504935-Sequence Alignment,
pubmed-meshheading:7504935-Sequence Homology
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pubmed:year |
1993
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pubmed:articleTitle |
A new type of G-->A hypermutation affecting human immunodeficiency virus.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway 08854.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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