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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1994-1-13
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pubmed:abstractText |
The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in culture against NMDA- but not kainate-mediated excitotoxicity. The effect was structure-dependent: larger macrolide rings were more active. Macrolides did not affect the 3-(2-carboxypiperazin-4yl)-propyl-1-phosphonic acid (CPP) binding or the NMDA-mediated calcium influx.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
624
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:7504570-Animals,
pubmed-meshheading:7504570-Anti-Bacterial Agents,
pubmed-meshheading:7504570-Cells, Cultured,
pubmed-meshheading:7504570-Cerebellum,
pubmed-meshheading:7504570-Dose-Response Relationship, Drug,
pubmed-meshheading:7504570-Glutamates,
pubmed-meshheading:7504570-Glutamic Acid,
pubmed-meshheading:7504570-Granulocytes,
pubmed-meshheading:7504570-Neurons,
pubmed-meshheading:7504570-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:7504570-Tacrolimus
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pubmed:year |
1993
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pubmed:articleTitle |
Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate.
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pubmed:affiliation |
FIDIA Research Laboratories, Abano Terme, Italy.
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pubmed:publicationType |
Journal Article
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