|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1994-1-4
|
|
pubmed:abstractText |
Induction of NO synthase expression by interleukin-1 beta in cultured vascular smooth muscle cells from rat aortas was accompanied by simultaneous induction of GTP: cyclohydrolase I. This enzyme regulates the de novo synthesis pathway for tetrahydrobiopterin, an essential cofactor for the catalytic conversion of L-arginine to L-citrulline and NO by inducible NO synthase. Inhibition of GTP: cyclohydrolase attenuated NO production by interleukin-1 beta-stimulated smooth muscle cells. Peptide growth factors such as fibroblast growth factor, platelet-derived growth factor and transforming growth factor beta 1 and the protease thrombin have been shown to modulate the production NO by cytokine-treated smooth muscle cells. These peptide agonists also regulated the induction of NO synthase and GTP: cyclohydrolase mRNA expression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
196
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1261-6
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7504472-Amino Acid Oxidoreductases,
pubmed-meshheading:7504472-Animals,
pubmed-meshheading:7504472-Aorta,
pubmed-meshheading:7504472-Blotting, Northern,
pubmed-meshheading:7504472-Cells, Cultured,
pubmed-meshheading:7504472-GTP Cyclohydrolase,
pubmed-meshheading:7504472-Gene Expression,
pubmed-meshheading:7504472-Growth Substances,
pubmed-meshheading:7504472-Interleukin-1,
pubmed-meshheading:7504472-Kinetics,
pubmed-meshheading:7504472-Muscle, Smooth, Vascular,
pubmed-meshheading:7504472-Nitric Oxide Synthase,
pubmed-meshheading:7504472-Platelet-Derived Growth Factor,
pubmed-meshheading:7504472-RNA, Messenger,
pubmed-meshheading:7504472-Rats,
pubmed-meshheading:7504472-Transforming Growth Factor beta
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Growth factor regulation of interleukin-1 beta-induced nitric oxide synthase and GTP: cyclohydrolase expression in cultured smooth muscle cells.
|
|
pubmed:affiliation |
Center for Experimental Therapeutics, Baylor College of Medicine, Houston, TX 77030.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
