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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1993-12-29
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pubmed:abstractText |
Neuropathologic studies of AIDS patients have shown that brain capillary endothelial cells are a cellular target for human immunodeficiency virus (HIV) in vivo. We have established in vitro cultures of primary human brain capillary endothelial (HBCE) cells. Using this model system, we have shown a significant HIV infection of HBCE cells that is productive yet noncytopathic. The infection is mediated by a cellular interaction with gp120 that does not involve CD4 or galactosylceramide. HIV infection of HBCE cells may contribute to AIDS-associated neuropathology by disturbing the physiology of the endothelium and directly or indirectly facilitating dissemination of virus to the central nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1337255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1371878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1376212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1457202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1513116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1586136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1592209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1671392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1702842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1710248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1716047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1857969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-1898974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2064772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2065887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2148832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2158692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2184372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2200125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2304148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2326646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2431105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2452899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2495565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2536142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2540236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2677235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2786088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2845276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2863599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2981429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-2999591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3016903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3018755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3277272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3296948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3472222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3472469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3532930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3548405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3639953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3644852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3646001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-3782302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-6100783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7504264-6139057
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10474-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7504264-Antigens, CD4,
pubmed-meshheading:7504264-Cells, Cultured,
pubmed-meshheading:7504264-Endothelium, Vascular,
pubmed-meshheading:7504264-Epitopes,
pubmed-meshheading:7504264-Fluorescent Antibody Technique,
pubmed-meshheading:7504264-Galactosylceramides,
pubmed-meshheading:7504264-HIV Envelope Protein gp120,
pubmed-meshheading:7504264-HIV Infections,
pubmed-meshheading:7504264-HIV-1,
pubmed-meshheading:7504264-Humans,
pubmed-meshheading:7504264-Receptors, Virus,
pubmed-meshheading:7504264-Virus Replication
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pubmed:year |
1993
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pubmed:articleTitle |
Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.
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pubmed:affiliation |
Department of Microbiology and Immunology, Oregon Health Sciences University, Portland 97201.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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