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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0042776,
umls-concept:C0081942,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0206243,
umls-concept:C0332307,
umls-concept:C1517806,
umls-concept:C1548328,
umls-concept:C1553412,
umls-concept:C2349975,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
1993-12-23
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pubmed:abstractText |
Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we systematically examined the surface expression of 19 different cell-adhesion molecules (CAMs) (the immunoglobulin superfamily, the homing receptors, the integrins, etc.) in a panel of 20 human T-cell lines (6 HTLV-1-negative lines and 14HTLV-1-positive lines). The surface expression of LFA-3 (CD58) was constantly enhanced in HTLV-1-positive T-cell lines except for MT-1, an ATL-derived cell line, which was devoid of a number of CAMs including ICAM-1. LFA-3 proteins and mRNA were found at strongly increased levels in HTLV-1-positive T-cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD43,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD58,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/UN1 sialoglycoprotein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
811-6
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pubmed:dateRevised |
2011-9-7
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pubmed:meshHeading |
pubmed-meshheading:7503960-Antigens, CD,
pubmed-meshheading:7503960-Antigens, CD2,
pubmed-meshheading:7503960-Antigens, CD28,
pubmed-meshheading:7503960-Antigens, CD43,
pubmed-meshheading:7503960-Antigens, CD44,
pubmed-meshheading:7503960-Antigens, CD58,
pubmed-meshheading:7503960-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:7503960-Blotting, Northern,
pubmed-meshheading:7503960-Cell Adhesion Molecules,
pubmed-meshheading:7503960-Flow Cytometry,
pubmed-meshheading:7503960-Fluorescent Antibody Technique,
pubmed-meshheading:7503960-Gene Expression,
pubmed-meshheading:7503960-Human T-lymphotropic virus 1,
pubmed-meshheading:7503960-Humans,
pubmed-meshheading:7503960-Immunoblotting,
pubmed-meshheading:7503960-Integrins,
pubmed-meshheading:7503960-Leukemia, T-Cell,
pubmed-meshheading:7503960-Membrane Glycoproteins,
pubmed-meshheading:7503960-RNA, Messenger,
pubmed-meshheading:7503960-Receptors, Immunologic,
pubmed-meshheading:7503960-Receptors, Lymphocyte Homing,
pubmed-meshheading:7503960-Sialoglycoproteins,
pubmed-meshheading:7503960-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1.
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pubmed:affiliation |
Shionogi Institute for Medical Science, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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