Linked Life Data

7503716

Source:http://linkedlifedata.com/resource/pubmed/id/7503716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-1-18
pubmed:abstractText
The purpose of this study was to determine whether epidermal growth factor (EGF) regulates mucous differentiation of airway epithelial cells in culture. Reduction of the EGF concentration below 25 ng/ml, which is the concentration routinely used in rat tracheal epithelial cell cultures, resulted in a 2 to 3-fold decrease in the percentage of mucous cells as determined by a mucin monoclonal antibody. The amount of secreted mucin decreased more than 10-fold within 5 days after reducing the EGF concentration. MUC5 gene expression, which was previously shown to correlate with mucous differentiation, was also reduced more than 8-fold. Addition of 25 ng/ml EGF to EGF-deprived cultures resulted in rapid induction of MUC5 expression. Following tissue injury and during inflammation the release of EGF and its functional analogue TGF alpha have been observed and may be involved in the mucus hypersecretion characteristic of many airway diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
412-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Epidermal growth factor regulates expression of the mucous phenotype of rat tracheal epithelial cells.
pubmed:affiliation
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
pubmed:publicationType
Journal Article