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pubmed-article:7503636pubmed:abstractTextTwo anthracycline drugs--doxorubicin and 4'-epidoxorubicin--synthesized at the Institute of Biotechnology and Antibiotics were tested in vivo for their biological activity in comparison with original Farmitalia drugs. In parallel experiments similar properties of both drugs and referentials were displayed: comparable subacute and delayed toxicity from i.p. and i.v. routes of administration as well as antitumor effectiveness in two mouse transplantable tumor models--P388 leukemia and B16 melanoma. No statistically significant differences between reproduced and original drugs were found.lld:pubmed
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pubmed-article:7503636pubmed:articleTitleComparative evaluation of toxicity and antitumor activity of original and reproduced anthracycline drugs.lld:pubmed
pubmed-article:7503636pubmed:affiliationDepartment of Tumor Immunology, Polish Academy of Sciences, Wroc?aw.lld:pubmed
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