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rdf:type |
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lifeskim:mentions |
umls-concept:C0020971,
umls-concept:C0024398,
umls-concept:C0037224,
umls-concept:C0039194,
umls-concept:C0042232,
umls-concept:C0457784,
umls-concept:C0871261,
umls-concept:C0971007,
umls-concept:C1522570,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:dateCreated |
1996-1-16
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pubmed:abstractText |
Rhesus monkeys were immunized by the vaginal and oral routes using a recombinant particulate simian immunodeficiency virus (SIV) antigen. Augmenting vaginal by oral immunization in macaques elicits proliferative CD4+ T cells in the circulation which are specific to the immunizing p27 antigen. Reconstitution of enriched CD4+ T cells, B cells and macrophages from circulating mononuclear cells help B cells in specific IgA anti-p27 antibody synthesis. The results suggest that augmented vaginal immunization induces systemic CD4+ T and B cell responses which may play a part in the protective immunity against SIV (HIV) infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
371B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1575-80
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:7502859-Administration, Intravaginal,
pubmed-meshheading:7502859-Administration, Oral,
pubmed-meshheading:7502859-Animals,
pubmed-meshheading:7502859-Antibodies, Viral,
pubmed-meshheading:7502859-Antigens, Viral,
pubmed-meshheading:7502859-B-Lymphocytes,
pubmed-meshheading:7502859-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7502859-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7502859-Female,
pubmed-meshheading:7502859-Gene Products, gag,
pubmed-meshheading:7502859-HIV Infections,
pubmed-meshheading:7502859-Humans,
pubmed-meshheading:7502859-Immunity, Mucosal,
pubmed-meshheading:7502859-Immunization,
pubmed-meshheading:7502859-Lymphocyte Activation,
pubmed-meshheading:7502859-Macaca fascicularis,
pubmed-meshheading:7502859-Macaca mulatta,
pubmed-meshheading:7502859-SAIDS Vaccines,
pubmed-meshheading:7502859-Simian immunodeficiency virus,
pubmed-meshheading:7502859-T-Lymphocytes,
pubmed-meshheading:7502859-Vagina
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pubmed:year |
1995
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pubmed:articleTitle |
T cell responses in macaques after vaginal immunization with particulate SIV p27 antigen.
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pubmed:affiliation |
Department of Immunology, UMDS, Guy's Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article
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