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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1996-1-18
|
| pubmed:abstractText |
A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0041-4301
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
275-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7502368-Antimetabolites, Antineoplastic,
pubmed-meshheading:7502368-Brain Diseases,
pubmed-meshheading:7502368-Child,
pubmed-meshheading:7502368-Diagnosis, Differential,
pubmed-meshheading:7502368-Female,
pubmed-meshheading:7502368-Humans,
pubmed-meshheading:7502368-Lymphoma, Non-Hodgkin,
pubmed-meshheading:7502368-Magnetic Resonance Imaging,
pubmed-meshheading:7502368-Methotrexate,
pubmed-meshheading:7502368-Tomography, X-Ray Computed
|
| pubmed:articleTitle |
Methotrexate-induced leukoencephalopathy. A case report.
|
| pubmed:affiliation |
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|