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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5242
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pubmed:dateCreated |
1996-1-18
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pubmed:abstractText |
Transcriptional silencing at the HMRa locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1 strain, which is defective for replication and silencing, complemented the silencing defect but not the replication defect; this result indicated that the replication and silencing functions of ORC were separable. The orc2-1 mutation mapped to the region of greatest homology between the Drosophila and yeast proteins. The silent state mediated by DmOrc2 was epigenetic; it was propagated during mitotic divisions in a relatively stable way, whereas the nonsilent state was metastable. In contrast, the silent state was erased during meiosis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1671-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7502078-Animals,
pubmed-meshheading:7502078-Cloning, Molecular,
pubmed-meshheading:7502078-DNA Replication,
pubmed-meshheading:7502078-DNA-Binding Proteins,
pubmed-meshheading:7502078-Drosophila Proteins,
pubmed-meshheading:7502078-Drosophila melanogaster,
pubmed-meshheading:7502078-Fungal Proteins,
pubmed-meshheading:7502078-Gene Expression Regulation,
pubmed-meshheading:7502078-Genes, Fungal,
pubmed-meshheading:7502078-Genes, Insect,
pubmed-meshheading:7502078-Genetic Complementation Test,
pubmed-meshheading:7502078-Mutation,
pubmed-meshheading:7502078-Origin Recognition Complex,
pubmed-meshheading:7502078-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:7502078-Replication Origin,
pubmed-meshheading:7502078-Repressor Proteins,
pubmed-meshheading:7502078-Saccharomyces cerevisiae,
pubmed-meshheading:7502078-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:7502078-Temperature,
pubmed-meshheading:7502078-Transformation, Genetic
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pubmed:year |
1995
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pubmed:articleTitle |
Separation of origin recognition complex functions by cross-species complementation.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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