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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5239
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pubmed:dateCreated |
1996-1-16
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pubmed:abstractText |
Interferon gamma (IFN-gamma) responsiveness in certain cells depends on the state of cellular differentiation or activation. Here an in vitro developmental system was used to show that IFN-gamma produced during generation of the CD4+ T helper cell type 1 (TH1) subset extinguishes expression of the IFN-gamma receptor beta subunit, resulting in TH1 cells that are unresponsive to IFN-gamma. This beta chain loss also occurred in IFN-gamma-treated TH2 cells and thus represents a specific response of CD4+ T cells to IFN-gamma rather than a TH1-specific differentiation event. These results define a mechanism of cellular desensitization where a cytokine down-regulates expression of a receptor subunit required primarily for signaling and not ligand binding.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
270
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1215-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7502050-Animals,
pubmed-meshheading:7502050-Antigens, CD,
pubmed-meshheading:7502050-Cell Differentiation,
pubmed-meshheading:7502050-Cell Line,
pubmed-meshheading:7502050-Cytokines,
pubmed-meshheading:7502050-Down-Regulation,
pubmed-meshheading:7502050-Gene Expression,
pubmed-meshheading:7502050-Genes, MHC Class I,
pubmed-meshheading:7502050-Interferon-gamma,
pubmed-meshheading:7502050-Ligands,
pubmed-meshheading:7502050-Mice,
pubmed-meshheading:7502050-Mice, Transgenic,
pubmed-meshheading:7502050-Receptors, Interferon,
pubmed-meshheading:7502050-Th1 Cells,
pubmed-meshheading:7502050-Th2 Cells
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pubmed:year |
1995
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pubmed:articleTitle |
Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.
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pubmed:affiliation |
Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article
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