Linked Life Data

7501279

Source:http://linkedlifedata.com/resource/pubmed/id/7501279

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-1-18
pubmed:abstractText
Barrington's nucleus, a pontine nucleus implicated in micturition, contains numerous corticotropin-releasing hormone (CRH) neurons that project to the spinal parasympathetic nucleus that innervates the bladder. We now report that CRH from Barrington's nucleus may serve to inhibit micturition. Selective chemical activation of Barrington's nucleus by microinjection of glutamate evoked bladder contractions that were increased in magnitude after intrathecal administration of a CRH antagonist, D-PheCRH12-41. In contrast, intrathecally administered CRH decreased the magnitude of Barrington's stimulated bladder contractions. These results suggest that activation of Barrington's nucleus releases an excitatory neurotransmitter responsible for bladder contractions, and CRH, which inhibits this neurotransmitter. The balance between these two neuromediators may regulate bladder contractility, and thereby, urinary continence.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Central regulation of micturition in the rat the corticotropin-releasing hormone from Barrington's nucleus.
pubmed:affiliation
Department of Psychiatry, Hahnemann University MS 403, Philadelphia, PA 19102-1192, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.