| pubmed-article:7500025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C1334291 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0069535 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0597721 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C1333707 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:7500025 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7500025 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7500025 | pubmed:dateCreated | 1996-1-17 | lld:pubmed |
| pubmed-article:7500025 | pubmed:abstractText | Oncostatin M (OSM) is a 28-kD glycoprotein recently identified as a growth factor for human multiple myeloma cells. It belongs to a family of distantly related cytokines that includes interleukin 6, ciliary neurotrophic factor, leukemia-inhibitory factor, and interleukin 11. These cytokines initiate signaling by inducing either homodimerization of gp130 or heterodimerization of gp130 with leukemia-inhibitory factor receptor beta components. Such dimerization in turn activates receptor-associated tyrosine kinases. In the present study using U266B1 human multiple myeloma cells, we show that OSM induces tyrosine phosphorylation and activation of JAK2, but not JAK1 or Tyk2, kinases. The results also demonstrate that OSM induces direct interaction of JAK2 kinase with Grb2, an SH2/SH3 domain containing adaptor protein. The SH2 domain of Grb2 is directly associated with tyrosine-phosphorylated JAK2. Furthermore, the presence of Sos in the JAK2-Grb2 complex suggests a role for Ras in OSM-transduced signaling. | lld:pubmed |
| pubmed-article:7500025 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7500025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7500025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7500025 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7500025 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:MalikNN | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:KufeD WDW | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:OgataAA | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:FrankDD | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:AndersonK CKC | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:UrashimaMM | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:ChauhanDD | lld:pubmed |
| pubmed-article:7500025 | pubmed:author | pubmed-author:KharbandaS... | lld:pubmed |
| pubmed-article:7500025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7500025 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7500025 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:7500025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7500025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7500025 | pubmed:pagination | 1801-6 | lld:pubmed |
| pubmed-article:7500025 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
| pubmed-article:7500025 | pubmed:meshHeading | pubmed-meshheading:7500025-... | lld:pubmed |
