Linked Life Data

7499855

Source:http://linkedlifedata.com/resource/pubmed/id/7499855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-1-18
pubmed:abstractText
IL-2-deficient mice were used to examine the role of endogenous IL-2 for supporting T cell proliferative responses during infection with lymphocytic choriomeningitis virus (LCMV). The studies showed that, although virus-specific CTL activity was induced in the absence of IL-2, the overall magnitude of the response was profoundly inhibited. Examination of proportions and numbers of CD8+ T cells demonstrated that the normal virus-induced expansion of these cells was virtually eliminated in spleens and dramatically decreased in lymph nodes from IL-2-negative mice. Absence of endogenous IL-2 also significantly inhibited virus-induced activated T cell production of IFN-gamma, as well as increases in frequencies and numbers of IFN-gamma-producing cells. Reductions in immune responses were accompanied by impaired viral clearance. Although T cell responses were dramatically reduced in IL-2-deficient, as compared with IL-2-containing mice, activation signals were being delivered in vivo because induced CTLs were sensitive to the cell cycle-specific toxin, hydroxyurea (HU), and CD8+ T cells had induced expression of the IL-2R alpha- and beta-chains. These studies demonstrated that, although low levels of T cell responses can be induced in the absence of IL-2, the factor plays a unique and critical role in supporting T cell proliferative responses in vivo and in optimizing induction of the biologic functions mediated by these cells. Furthermore, the results identify a role for IL-2 in promoting IFN-gamma production in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5690-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.
pubmed:affiliation
Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.