Linked Life Data

7498264

Source:http://linkedlifedata.com/resource/pubmed/id/7498264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1996-1-18
pubmed:abstractText
We examined the effect of urethane (1000 mg/kg, followed by 50 mg/kg per h, i.v.), an anesthetic commonly used by physiologists, on evoked potentials recorded in dentate gyrus in adult Wistar rats by stimulating the ipsilateral perforant path, via chronically implanted electrodes. Urethane decreased paired-pulse inhibition. Under urethane, with paired-pulse stimulation, the ratio of the second population spike amplitude to the first increased by 11.1-20.7% at 25-60 ms interstimulus interval (n = 18, P < 0.05). At 25 ms, the proportion was 3.6 +/- 1.6 while awake, and 14.7 +/- 3.5 under urethane. Urethane depressed granule cell excitability and strength of synaptic responses. Under urethane, the ratio of the population spike amplitude obtained at 250 microA stimulation to the maximal response in the same input/output response examination decreased by 20%, and the ratio of the excitatory postsynaptic response slopes fell by 10%. These results indicate that urethane affects neurotransmission in the hippocampus, and suggest that its effect may be exerted in part on excitatory neurotransmission.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The effect of urethane anesthesia on evoked potentials in dentate gyrus.
pubmed:affiliation
Epilepsy Research Laboratory, Veterans Affairs Medical Center, Sepulveda, CA 91343-2099, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.