Linked Life Data

7498251

Source:http://linkedlifedata.com/resource/pubmed/id/7498251

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-1-18
pubmed:abstractText
Neuroglycopenia induced by administration of 2-deoxy-D-glucose is known to stimulate the secretion of both insulin and glucagon in mice by a mechanism that is dependent on neural activity. In the present study, we examined whether the neurotransmitter nitric oxide (NO) is involved in this process. Therefore, 2-deoxy-D-glucose (500 mg/kg) was injected intravenously alone or together with the inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (50 mg/kg) to conscious mice. It was found that NG-nitro-L-arginine methyl ester inhibited the increased plasma levels of both insulin (by 26%; P = 0.039) and glucagon (by 45%; P < 0.001) at 10 min after injection of 2-deoxy-D-glucose. Similarly, the NO synthase inhibitor, NG-nitro-L-arginine, which is devoid of the anticholinergic property of NG-nitro-L-arginine methyl ester, inhibited the responses of both insulin (by 53%; P = 0.026) and glucagon (by 57%; P = 0.003) to 2-deoxy-D-glucose. In contrast, the stereoisomer of NG-nitro-L-arginine methyl ester, NG-nitro-D-arginine methyl ester, which is devoid of NO synthase inhibitory activity, was without effect on 2-deoxy-D-glucose-induced insulin and glucagon secretion. Plasma levels of adrenaline and noradrenaline after administration of 2-deoxy-D-glucose were also reduced by NG-nitro-L-arginine methyl ester. In contrast, the insulin and glucagon secretory responses to intravenous injection of arginine (250 mg/kg), glucose (500 mg/kg) or the cholinergic agonist, carbachol (30 micrograms/kg), were not influenced by NG-nitro-L-arginine methyl ester, NG-nitro-D-arginine methyl ester or NG-nitro-L-arginine.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-35
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:7498251-Animals, pubmed-meshheading:7498251-Arginine, pubmed-meshheading:7498251-Blood Glucose, pubmed-meshheading:7498251-Carbachol, pubmed-meshheading:7498251-Catecholamines, pubmed-meshheading:7498251-Chronic Disease, pubmed-meshheading:7498251-Deoxyglucose, pubmed-meshheading:7498251-Drug Interactions, pubmed-meshheading:7498251-Female, pubmed-meshheading:7498251-Hypoglycemia, pubmed-meshheading:7498251-Insulin, pubmed-meshheading:7498251-Islets of Langerhans, pubmed-meshheading:7498251-Mice, pubmed-meshheading:7498251-Mice, Inbred Strains, pubmed-meshheading:7498251-NG-Nitroarginine Methyl Ester, pubmed-meshheading:7498251-Nitric Oxide, pubmed-meshheading:7498251-Nitric Oxide Synthase, pubmed-meshheading:7498251-Nitroarginine, pubmed-meshheading:7498251-Stimulation, Chemical
pubmed:year
1995
pubmed:articleTitle
Involvement of nitric oxide in neuroglycopenia-induced insulin and glucagon secretion in the mouse.
pubmed:affiliation
Department of Medicine, Lund University, Malmö, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't