rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
1996-1-17
|
pubmed:abstractText |
A line of evidence indicates changes of the immune system in schizophrenic patients. We investigated the production of cytokines by peripheral blood mononuclear cells (PBMCs) in drug-free and neuroleptic-treated schizophrenic patients compared to healthy, normal controls. A significant reduction in interleukin (IL)-2 production was detected in untreated schizophrenic patients (-59.6%; p < .05) as well as in IL-3-like activity (IL-3-LA) production (-27.4%; p < .05) in treated patients compared to controls. No alteration was observed in IL-1 beta production. It seems that schizophrenia is associated with diminished IL-2 production, while neuroleptic treatment interferes with the capacity of immunocompetent cells to synthesize and/or release Il-3-LA. The alteration in cytokine production did not correlate with either the severity of the disorder or the serum prolactin levels.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0006-3223
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
38
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
297-302
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7495923-Adult,
pubmed-meshheading:7495923-Antipsychotic Agents,
pubmed-meshheading:7495923-Cytokines,
pubmed-meshheading:7495923-Female,
pubmed-meshheading:7495923-Humans,
pubmed-meshheading:7495923-Interleukin-1,
pubmed-meshheading:7495923-Interleukin-2,
pubmed-meshheading:7495923-Interleukin-3,
pubmed-meshheading:7495923-Male,
pubmed-meshheading:7495923-Middle Aged,
pubmed-meshheading:7495923-Monocytes,
pubmed-meshheading:7495923-Prolactin,
pubmed-meshheading:7495923-Reference Values,
pubmed-meshheading:7495923-Schizophrenia,
pubmed-meshheading:7495923-Schizophrenic Psychology
|
pubmed:year |
1995
|
pubmed:articleTitle |
Cytokine production in drug-free and neuroleptic-treated schizophrenic patients.
|
pubmed:affiliation |
Hematology Research Laboratory, Hasharon Hospital Golda Medical Center, Petah-Tikva, Israel.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|