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pubmed-article:7494321pubmed:abstractTextMajor histocompatibility complex (MHC) class I ligand motifs have been defined for a number of class I molecules and have been successfully used to identify class I-restricted cytotoxic T-cell epitopes. In contrast, the relative degeneracy of sequence motifs in naturally processed MHC class II ligands has suggested that they may be of more limited use. Here, we use a predicted I-Ab ligand motif to identify antigenic peptides in the Sendai virus Enders strain matrix (M) protein. The entire coding sequence of the M protein was derived, and seven peptide sequences that contained the predicted I-Ab motif were identified. Analysis of I-Ab-restricted M-specific T-cell hybridomas for reactivity to these synthetic peptides identified two distinct epitopes. These data demonstrate that MHC class II motifs can be valuable in predicting T-cell epitopes.lld:pubmed
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pubmed-article:7494321pubmed:articleTitleBinding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.lld:pubmed
pubmed-article:7494321pubmed:affiliationDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.lld:pubmed
pubmed-article:7494321pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7494321pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:7494321pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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