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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1996-1-11
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pubmed:databankReference |
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pubmed:abstractText |
Major histocompatibility complex (MHC) class I ligand motifs have been defined for a number of class I molecules and have been successfully used to identify class I-restricted cytotoxic T-cell epitopes. In contrast, the relative degeneracy of sequence motifs in naturally processed MHC class II ligands has suggested that they may be of more limited use. Here, we use a predicted I-Ab ligand motif to identify antigenic peptides in the Sendai virus Enders strain matrix (M) protein. The entire coding sequence of the M protein was derived, and seven peptide sequences that contained the predicted I-Ab motif were identified. Analysis of I-Ab-restricted M-specific T-cell hybridomas for reactivity to these synthetic peptides identified two distinct epitopes. These data demonstrate that MHC class II motifs can be valuable in predicting T-cell epitopes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1319610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1328884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1382144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1534240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1546328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1656276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1700303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1700304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1709722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1719425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-1922338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-2161155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-2427638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-2443855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-3110276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-3518750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-6238333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7504010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7508998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7511662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7523695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7685408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7686314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7890324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-7937075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-8119729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-8145819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-8176210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-8315383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7494321-8476565
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8057-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7494321-Amino Acid Sequence,
pubmed-meshheading:7494321-Animals,
pubmed-meshheading:7494321-Base Sequence,
pubmed-meshheading:7494321-Binding Sites,
pubmed-meshheading:7494321-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7494321-Epitopes,
pubmed-meshheading:7494321-Histocompatibility Antigens Class II,
pubmed-meshheading:7494321-Hybridomas,
pubmed-meshheading:7494321-L Cells (Cell Line),
pubmed-meshheading:7494321-Mice,
pubmed-meshheading:7494321-Molecular Sequence Data,
pubmed-meshheading:7494321-Parainfluenza Virus 1, Human,
pubmed-meshheading:7494321-Peptide Fragments,
pubmed-meshheading:7494321-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:7494321-Viral Matrix Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Binding motifs predict major histocompatibility complex class II-restricted epitopes in the Sendai virus M protein.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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