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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0012854,
umls-concept:C0017337,
umls-concept:C0021311,
umls-concept:C0023767,
umls-concept:C0024141,
umls-concept:C0086418,
umls-concept:C0208973,
umls-concept:C0524637,
umls-concept:C1517892,
umls-concept:C1554184,
umls-concept:C1704666,
umls-concept:C2700640
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pubmed:issue |
2
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|
pubmed:dateCreated |
1996-1-11
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pubmed:databankReference |
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pubmed:abstractText |
The VH4-21 (V4-34) gene segment, a member of the VH4 family, is expressed early in B-cell maturation and is utilized by approximately 6% of normal adult B lymphocytes. This prevalence indicates an importance of VH4-21 in the B-cell repertoire. The gene also encodes certain autoantibodies being mandatory for pathological IgM anti-red cell antibodies directed against the I/i antigen, and also capable of encoding anti-DNA antibodies. Recognition of I/i antigen or DNA appears to be via two distinct sites on VH, with I/i binding mediated by sequences in the framework region, and DNA binding correlating with the presence of positively charged amino acids in complementarity-determining region 3. However, these positively charged residues appear to suppress the ability of the framework region to interact with I/i, rendering a single sequence monospecific for I/i or DNA. The IgM anti-DNA antibodies also recognize bacterial lipid A, whereas the anti-I/i antibodies do not, indicating that CDR3 may be involved in binding the negatively charged lipid A. Structural similarities between the DNA backbone and lipid A provide a possible explanation for this cross-reactivity. This dual recognition of bacterial antigen and autoantigen provides a potential link between infection and autoimmunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0956-960X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
52-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7492751-Adult,
pubmed-meshheading:7492751-Amino Acid Sequence,
pubmed-meshheading:7492751-Anemia, Hemolytic, Autoimmune,
pubmed-meshheading:7492751-Antibodies, Antinuclear,
pubmed-meshheading:7492751-Antibody Specificity,
pubmed-meshheading:7492751-Antigens, Bacterial,
pubmed-meshheading:7492751-Autoantigens,
pubmed-meshheading:7492751-Cross Reactions,
pubmed-meshheading:7492751-DNA,
pubmed-meshheading:7492751-Genes, Immunoglobulin,
pubmed-meshheading:7492751-Hemagglutination,
pubmed-meshheading:7492751-Humans,
pubmed-meshheading:7492751-Immunoglobulin M,
pubmed-meshheading:7492751-Immunoglobulin Variable Region,
pubmed-meshheading:7492751-Lipid A,
pubmed-meshheading:7492751-Molecular Sequence Data,
pubmed-meshheading:7492751-Sequence Alignment,
pubmed-meshheading:7492751-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus.
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pubmed:affiliation |
Tenovus Laboratory, Southampton University Hospitals, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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