| pubmed-article:7492701 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0036111 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C1185740 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0037868 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0748342 | lld:lifeskim |
| pubmed-article:7492701 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7492701 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7492701 | pubmed:dateCreated | 1996-1-11 | lld:pubmed |
| pubmed-article:7492701 | pubmed:abstractText | Induction of immune responses in the reproductive tract will be crucial for a functional gamete antigen-based antifertility vaccine. Here we describe the construction and development of an avirulent Salmonella as an oral vaccine delivery vector to elicit sperm-specific immune responses in reproductive tract secretions. A cDNA sequence encoding the human sperm antigen SP10 was cloned on an asd+vector and expressed to a high level in an avirulent delta cya, delta crp, and delta asd vaccine strain of Salmonella typhimurium. Oral immunization of female BALB/c mice with this recombinant Salmonella elicited high-titer anti-SP10 IgG antibodies in serum and IgA antibodies in vaginal secretions. Anti-SP10 antibody titers could be increased by secondary and tertiary oral administrations of the recombinant Salmonella. Induction of sperm-specific antibodies in the reproductive tract following oral administration of a recombinant Salmonella could lead to the development of a simple, safe, efficient, and easy-to-use antifertility vaccine. | lld:pubmed |
| pubmed-article:7492701 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7492701 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492701 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7492701 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7492701 | pubmed:issn | 0006-3363 | lld:pubmed |
| pubmed-article:7492701 | pubmed:author | pubmed-author:WrightRR | lld:pubmed |
| pubmed-article:7492701 | pubmed:author | pubmed-author:CurtissRR3rd | lld:pubmed |
| pubmed-article:7492701 | pubmed:author | pubmed-author:HerrJ CJC | lld:pubmed |
| pubmed-article:7492701 | pubmed:author | pubmed-author:SrinivasanJJ | lld:pubmed |
| pubmed-article:7492701 | pubmed:author | pubmed-author:TingeSS | lld:pubmed |
| pubmed-article:7492701 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7492701 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:7492701 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7492701 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7492701 | pubmed:pagination | 462-71 | lld:pubmed |
| pubmed-article:7492701 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7492701 | pubmed:meshHeading | pubmed-meshheading:7492701-... | lld:pubmed |
| pubmed-article:7492701 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7492701 | pubmed:articleTitle | Oral immunization with attenuated Salmonella expressing human sperm antigen induces antibodies in serum and the reproductive tract. | lld:pubmed |
| pubmed-article:7492701 | pubmed:affiliation | Department of Biology, Washington University, St. Louis, Missouri 63130, USA. | lld:pubmed |
| pubmed-article:7492701 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7492701 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7492701 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7492701 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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