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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1996-1-3
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pubmed:abstractText |
The effect of the anti-oestrogen tamoxifen on bone density in post-menopausal women with stage II breast cancer (n = 35) was compared with two untreated hypo-oestrogenaemic groups (premature ovarian failure, n = 20; prolactinoma, n = 19) and a group of women with prolactinomas and normal oestrogen levels (n = 12). Bone densities were normal in the euoestrogenaemic groups, but significantly reduced in both hypo-oestrogenaemic groups. Repeat measurements were available for 31 of the 35 tamoxifen-treated subjects after an interval of 33.9 +/- 14.7 months. The anti-oestrogen action of tamoxifen was not associated with accelerated bone loss of the spine or hip, an outcome that was clearly demonstrable in hypo-oestrogenaemic disorders.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0143-3636
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
698-702
|
pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7491184-Adult,
pubmed-meshheading:7491184-Analysis of Variance,
pubmed-meshheading:7491184-Antineoplastic Agents, Hormonal,
pubmed-meshheading:7491184-Bone Density,
pubmed-meshheading:7491184-Breast Neoplasms,
pubmed-meshheading:7491184-Female,
pubmed-meshheading:7491184-Follow-Up Studies,
pubmed-meshheading:7491184-Humans,
pubmed-meshheading:7491184-Middle Aged,
pubmed-meshheading:7491184-Pituitary Neoplasms,
pubmed-meshheading:7491184-Postmenopause,
pubmed-meshheading:7491184-Primary Ovarian Insufficiency,
pubmed-meshheading:7491184-Prolactinoma,
pubmed-meshheading:7491184-Tamoxifen,
pubmed-meshheading:7491184-Time Factors
|
pubmed:year |
1995
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pubmed:articleTitle |
Oestrogen and bone density: a comparison of tamoxifen and hypo-oestrogenaemia.
|
pubmed:affiliation |
Department of Medicine, University of Manitoba, St Boniface General Hospital, Winnipeg, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study
|