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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1996-1-4
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pubmed:abstractText |
Atherosclerotic changes have not been demonstrated directly in asymptomatic hyperglycaemic non-diabetic subjects, although high mortality due to coronary heart disease has been reported. We measured arterial wall thickness non-invasively, in order to directly demonstrate atherosclerosis of the carotid arteries of hyperglycaemic non-diabetic subjects and to evaluate its risk factors. The thicknesses of the intimal plus medial complex (IMT) of the carotid arteries of 112 asymptomatic hyperglycaemic non-diabetic subjects (aged 22-81, 95 males and 17 females) were compared with those of 55 healthy male subjects and 211 non-insulin-dependent NIDDM male diabetic patients. The subjects were subgrouped into impaired glucose-tolerant (IGT) subjects who had a 2-h glycaemic level of more than 7.8 mmol/l, and non-IGT subjects whose 2-h glycaemic levels were within 6.7-7.7 mmol/l. Non-IGT and IGT subjects showed significantly greater IMTs than age-matched healthy males and showed no significant differences compared to age-matched NIDDM patients. Multivariate analysis demonstrated that the risk factors for IMT of non-IGT and IGT subjects were age and systolic blood pressure. According to data on the accumulation of atherogenic risks (hypertension, dyslipidaemia, and smoking), IMT increased linearly in non-IGT and IGT subjects. However, non-IGT and IGT subjects without hyperlipidaemia, hypertension, or smoking risk still had significantly greater IMT than age-matched normal males (1.019 +/- 0.063 vs 0.770 +/- 0.111 mm, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-186X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7489842-Adult,
pubmed-meshheading:7489842-Age Factors,
pubmed-meshheading:7489842-Aged,
pubmed-meshheading:7489842-Aged, 80 and over,
pubmed-meshheading:7489842-Analysis of Variance,
pubmed-meshheading:7489842-Arteriosclerosis,
pubmed-meshheading:7489842-Carotid Arteries,
pubmed-meshheading:7489842-Coronary Disease,
pubmed-meshheading:7489842-Diabetes Mellitus, Type 2,
pubmed-meshheading:7489842-Electrocardiography,
pubmed-meshheading:7489842-Female,
pubmed-meshheading:7489842-Glucose Intolerance,
pubmed-meshheading:7489842-Humans,
pubmed-meshheading:7489842-Hyperglycemia,
pubmed-meshheading:7489842-Male,
pubmed-meshheading:7489842-Middle Aged,
pubmed-meshheading:7489842-Reference Values,
pubmed-meshheading:7489842-Regression Analysis,
pubmed-meshheading:7489842-Tunica Media
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pubmed:year |
1995
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pubmed:articleTitle |
Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery.
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pubmed:affiliation |
First Department of Medicine, Osaka University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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