Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-1-4
pubmed:abstractText
Atherosclerotic changes have not been demonstrated directly in asymptomatic hyperglycaemic non-diabetic subjects, although high mortality due to coronary heart disease has been reported. We measured arterial wall thickness non-invasively, in order to directly demonstrate atherosclerosis of the carotid arteries of hyperglycaemic non-diabetic subjects and to evaluate its risk factors. The thicknesses of the intimal plus medial complex (IMT) of the carotid arteries of 112 asymptomatic hyperglycaemic non-diabetic subjects (aged 22-81, 95 males and 17 females) were compared with those of 55 healthy male subjects and 211 non-insulin-dependent NIDDM male diabetic patients. The subjects were subgrouped into impaired glucose-tolerant (IGT) subjects who had a 2-h glycaemic level of more than 7.8 mmol/l, and non-IGT subjects whose 2-h glycaemic levels were within 6.7-7.7 mmol/l. Non-IGT and IGT subjects showed significantly greater IMTs than age-matched healthy males and showed no significant differences compared to age-matched NIDDM patients. Multivariate analysis demonstrated that the risk factors for IMT of non-IGT and IGT subjects were age and systolic blood pressure. According to data on the accumulation of atherogenic risks (hypertension, dyslipidaemia, and smoking), IMT increased linearly in non-IGT and IGT subjects. However, non-IGT and IGT subjects without hyperlipidaemia, hypertension, or smoking risk still had significantly greater IMT than age-matched normal males (1.019 +/- 0.063 vs 0.770 +/- 0.111 mm, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
585-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7489842-Adult, pubmed-meshheading:7489842-Age Factors, pubmed-meshheading:7489842-Aged, pubmed-meshheading:7489842-Aged, 80 and over, pubmed-meshheading:7489842-Analysis of Variance, pubmed-meshheading:7489842-Arteriosclerosis, pubmed-meshheading:7489842-Carotid Arteries, pubmed-meshheading:7489842-Coronary Disease, pubmed-meshheading:7489842-Diabetes Mellitus, Type 2, pubmed-meshheading:7489842-Electrocardiography, pubmed-meshheading:7489842-Female, pubmed-meshheading:7489842-Glucose Intolerance, pubmed-meshheading:7489842-Humans, pubmed-meshheading:7489842-Hyperglycemia, pubmed-meshheading:7489842-Male, pubmed-meshheading:7489842-Middle Aged, pubmed-meshheading:7489842-Reference Values, pubmed-meshheading:7489842-Regression Analysis, pubmed-meshheading:7489842-Tunica Media
pubmed:year
1995
pubmed:articleTitle
Asymptomatic hyperglycaemia is associated with increased intimal plus medial thickness of the carotid artery.
pubmed:affiliation
First Department of Medicine, Osaka University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't