| pubmed-article:7489743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C0004364 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C0205246 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C0205318 | lld:lifeskim |
| pubmed-article:7489743 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:7489743 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7489743 | pubmed:dateCreated | 1996-1-4 | lld:pubmed |
| pubmed-article:7489743 | pubmed:abstractText | Interleukin-2-deficient mice (IL-2-/-) crossed to a BALB/c genetic background develop a lymphoproliferative syndrome with severe hemolytic anemia and die within 5 weeks of age. The presence of autoantibodies of various specificities and inflammatory lesions in several organs are indicative of a generalized auto-immune disease. No alterations of the immune system were observed in 6-day-old animals, but 10-day-old mice already showed an increased proliferation and polyclonal activation of lymphocytes. The treatment of IL-2-/- mice with anti-gp39(CD40L) antibody prevented the disease and indicated that the appearance of activated CD4- T cells (CD44high, CD69-) represents the first alteration of the immune system in IL-2-/- mice. Collectively, our results suggest that an essential role of IL-2 in vivo, which is not compensated by other cytokines, is the maintenance of self tolerance. | lld:pubmed |
| pubmed-article:7489743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7489743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7489743 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7489743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7489743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7489743 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7489743 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:HoralJJ | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:LöhlerJJ | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:HaberHH | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:SickelEE | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:NoelleR JRJ | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:SadlackBB | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:SchorleHH | lld:pubmed |
| pubmed-article:7489743 | pubmed:author | pubmed-author:KlebbGG | lld:pubmed |
| pubmed-article:7489743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7489743 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7489743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7489743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7489743 | pubmed:pagination | 3053-9 | lld:pubmed |
| pubmed-article:7489743 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7489743 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7489743 | pubmed:articleTitle | Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. | lld:pubmed |
| pubmed-article:7489743 | pubmed:affiliation | Institute of Virology and Immunobiology, University of Würburg, Germany. | lld:pubmed |
| pubmed-article:7489743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7489743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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