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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1996-1-4
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pubmed:abstractText |
Interleukin-2-deficient mice (IL-2-/-) crossed to a BALB/c genetic background develop a lymphoproliferative syndrome with severe hemolytic anemia and die within 5 weeks of age. The presence of autoantibodies of various specificities and inflammatory lesions in several organs are indicative of a generalized auto-immune disease. No alterations of the immune system were observed in 6-day-old animals, but 10-day-old mice already showed an increased proliferation and polyclonal activation of lymphocytes. The treatment of IL-2-/- mice with anti-gp39(CD40L) antibody prevented the disease and indicated that the appearance of activated CD4- T cells (CD44high, CD69-) represents the first alteration of the immune system in IL-2-/- mice. Collectively, our results suggest that an essential role of IL-2 in vivo, which is not compensated by other cytokines, is the maintenance of self tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3053-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7489743-Anemia, Hemolytic, Autoimmune,
pubmed-meshheading:7489743-Animals,
pubmed-meshheading:7489743-Animals, Newborn,
pubmed-meshheading:7489743-Antibodies, Monoclonal,
pubmed-meshheading:7489743-Autoimmune Diseases,
pubmed-meshheading:7489743-B-Lymphocytes,
pubmed-meshheading:7489743-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7489743-CD40 Ligand,
pubmed-meshheading:7489743-Immunoglobulin G,
pubmed-meshheading:7489743-Immunoglobulin M,
pubmed-meshheading:7489743-Interleukin-2,
pubmed-meshheading:7489743-Ligands,
pubmed-meshheading:7489743-Lymphocyte Activation,
pubmed-meshheading:7489743-Membrane Glycoproteins,
pubmed-meshheading:7489743-Mice,
pubmed-meshheading:7489743-Mice, Inbred BALB C,
pubmed-meshheading:7489743-Mice, Mutant Strains
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pubmed:year |
1995
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pubmed:articleTitle |
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.
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pubmed:affiliation |
Institute of Virology and Immunobiology, University of Würburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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