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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1996-1-2
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pubmed:abstractText |
The receptor for granulocyte colony-stimulating factor (G-CSFR) is a hemopoietic growth factor receptor, which mediates proliferation and differentiation signals. The cytoplasmic region of G-CSFR carries four tyrosine residues in its C-terminal half. We constructed mutant receptors in which each tyrosine residue of G-CSFR was mutated to phenylalanine. Two mutant receptors (Tyr703 and Tyr728) neither transduced the growth-inhibitory signal nor induced the neutrophil-specific myeloperoxidase (MPO) gene. The Tyr703 mutant did not induce morphological changes in cells, whereas transformants expressing the Tyr728 mutant adhered to plates with a macrophage-like morphology upon G-CSF stimulation. Mutation of the most distal tyrosine residue (Tyr763) abolished the ability of G-CSFR to stimulate the tyrosine phosphorylation of a cellular protein with an M(r) of 54 kDa. These results indicated that the regions around the three tyrosine residues of G-CSFR play essential and distinct roles in signal transduction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1326293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1412701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1534271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1566332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1695833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1696260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1701053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1708811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1717255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1720034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-1723014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2147944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2158861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2171545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2469962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2473791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2548170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-2564392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-3489940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-6330085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7503988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7512451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7512720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7521686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7521688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7522448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7531822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7678333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7681146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7691413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7716810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7834738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7834741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7845468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-7871433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8048164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8134361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8197119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8197455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8199352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8246993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7489718-8293462
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5288-96
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7489718-Animals,
pubmed-meshheading:7489718-Base Sequence,
pubmed-meshheading:7489718-Cell Differentiation,
pubmed-meshheading:7489718-Cell Division,
pubmed-meshheading:7489718-Gene Deletion,
pubmed-meshheading:7489718-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:7489718-Mice,
pubmed-meshheading:7489718-Molecular Sequence Data,
pubmed-meshheading:7489718-Neutrophils,
pubmed-meshheading:7489718-Peroxidase,
pubmed-meshheading:7489718-Point Mutation,
pubmed-meshheading:7489718-Receptors, Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:7489718-Signal Transduction,
pubmed-meshheading:7489718-Tumor Cells, Cultured,
pubmed-meshheading:7489718-Tyrosine
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pubmed:year |
1995
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pubmed:articleTitle |
Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor.
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pubmed:affiliation |
Osaka Bioscience Institute, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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