| pubmed-article:7489567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0460004 | lld:lifeskim |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0439859 | lld:lifeskim |
| pubmed-article:7489567 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7489567 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7489567 | pubmed:dateCreated | 1996-1-4 | lld:pubmed |
| pubmed-article:7489567 | pubmed:abstractText | Tumour-infiltrating lymphocytes (TIL) and tumours from six patients with squamous cell carcinomas of the head and neck (SCCHN) were investigated. The six tumours all expressed major histocompatibility complex (MHC) class I antigens both in vivo and as tumor cell lines grown in vitro. In addition, the cancer cells either overexpressed the tumour-suppressor gene product p53 or harboured human papilloma virus 16/18 (HPV). The TIL were expanded in vitro in the presence of interleukin-2, immobilised anti-CD3 mAb and soluble anti-CD28 mAb. Expanded TIL cultures contained both CD4+ and CD8+ T cells, but generally contained few CD56+CD3- cells of the natural killer (NK) phenotype. CD8+ T cells dominated the individual TIL cultures from five of the six patients and showed significant autologous tumour cell lysis. In TIL cultures derived from four of these tumour-reactive TIL cultures, killing could be partially blocked by an anti-MHC class I mAb. TIL cultures reacting with autologous tumour cells also showed strong TCR/CD3-redirected cytotoxicity when assayed against hybridoma cells expressing anti-TCR/CD3 mAb as well as natural-killer(NK)-like activity. A number of TIL cultures devoid of autologous tumour cell lysis were capable of lysing the natural-killer(NK)-sensitive K562 cell line suggesting that the SCCHN cells themselves are resistant to NK-like lysis. In conclusion, TIL cultures from head and neck carcinomas contain T cells which, upon expansion in vitro, can lyse autologous tumour cells in a MHC-class-I-restricted fashion. Thus, the results of the present study document that carcinomas of the head and neck in some patients are infiltrated by cytotoxic T cell precursors potentially capable of rejecting the autologous tumour. | lld:pubmed |
| pubmed-article:7489567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7489567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7489567 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7489567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7489567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7489567 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7489567 | pubmed:issn | 0340-7004 | lld:pubmed |
| pubmed-article:7489567 | pubmed:author | pubmed-author:HaldJJ | lld:pubmed |
| pubmed-article:7489567 | pubmed:author | pubmed-author:ClaessonM HMH | lld:pubmed |
| pubmed-article:7489567 | pubmed:author | pubmed-author:RasmussenNN | lld:pubmed |
| pubmed-article:7489567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7489567 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:7489567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7489567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7489567 | pubmed:pagination | 243-50 | lld:pubmed |
| pubmed-article:7489567 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:meshHeading | pubmed-meshheading:7489567-... | lld:pubmed |
| pubmed-article:7489567 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7489567 | pubmed:articleTitle | Tumour-infiltrating lymphocytes mediate lysis of autologous squamous cell carcinomas of the head and neck. | lld:pubmed |
| pubmed-article:7489567 | pubmed:affiliation | Department of Otolaryngology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark. | lld:pubmed |
| pubmed-article:7489567 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7489567 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7489567 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7489567 | lld:pubmed |
