| pubmed-article:7488145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0022022 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C1979572 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C1980044 | lld:lifeskim |
| pubmed-article:7488145 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:7488145 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7488145 | pubmed:dateCreated | 1995-12-21 | lld:pubmed |
| pubmed-article:7488145 | pubmed:abstractText | The mouse CD5 positive pre-B cell line SPGM-1 can be induced to switch its lineage commitment towards macrophage differentiation by treatment with a combination of phorbol ester and a calcium ionophore. When cultured with these reagents the pre-B cells ceased to proliferate and rapidly became adherent to plastic surfaces. This morphological change was accompanied by the loss of pre-B cell-specific surface markers, such as PB76 and most prominently the mu heavy chain of the immunoglobulin receptor complex. In addition, the mRNA of the surrogate light chain lambda 5 disappeared while the induction of lysozyme mRNA could be detected. Differentiated SPGM-1 cells phagocytosed latex beads and showed nonspecific esterase activity. The high efficiency and speed of differentiation in this cellular system makes SPGM-1 a highly suitable model for studying the phenomenon of lineage switching during hemopoesis. | lld:pubmed |
| pubmed-article:7488145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7488145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7488145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7488145 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7488145 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7488145 | pubmed:author | pubmed-author:MartinMM | lld:pubmed |
| pubmed-article:7488145 | pubmed:author | pubmed-author:ReschKK | lld:pubmed |
| pubmed-article:7488145 | pubmed:author | pubmed-author:NeumannDD | lld:pubmed |
| pubmed-article:7488145 | pubmed:author | pubmed-author:StrasserAA | lld:pubmed |
| pubmed-article:7488145 | pubmed:author | pubmed-author:SpenckerTT | lld:pubmed |
| pubmed-article:7488145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7488145 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:7488145 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:7488145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7488145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7488145 | pubmed:pagination | 540-8 | lld:pubmed |
| pubmed-article:7488145 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7488145 | pubmed:meshHeading | pubmed-meshheading:7488145-... | lld:pubmed |
| pubmed-article:7488145 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7488145 | pubmed:articleTitle | Lineage switch of a mouse pre-B cell line (SPGM-1) to macrophage-like cells after incubation with phorbol ester and calcium ionophore. | lld:pubmed |
| pubmed-article:7488145 | pubmed:affiliation | Institute of Molecular Pharmacology, Medical School Hannover, Germany. | lld:pubmed |
| pubmed-article:7488145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7488145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
