Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-11-30
|
| pubmed:abstractText |
Subsurface soil from a National Priorities List landfill containing about 2.5% polychlorinated biphenyls (PCBs) was extracted and the extract cleaned by Florisil slurry and alumina column chromatography. The refined extract contained 48 mg/mL PCB, mainly trichlorobiphenyls and tetrachlorobiphenyls, traces of polychlorinated naphthalenes, 125 micrograms/mL 2,2-bis-p-chlorophenyl-1,1-dichloroethylene (DDE), and low levels of chlorinated dibenzofurans. The refined extract was dissolved in corn oil and administered intraperitoneally to weanling (day 20) female rats on days 20 and 21; rats were terminated on day 22. Limited data indicated possible hematopoietic effects, including neutrophilia. There were no changes in relative uterus, kidney, or adrenal gland weights between total doses of 3 to 96 mg/kg total PCB. Relative liver weights increased significantly at 36 mg/kg and activities of P450s 1A1 (as ethoxyresorufin O-dealkylase) and 2B (as pentoxyresorufin O-dealkylase) increased at 12 mg/kg and plateaued at 36 (P450 1A1) or 48 (P450 2b) mg/kg. Serum total thyroxine (T4) declined significantly at doses of 36 mg/kg and greater; thyroid follicular epithelial cells were significantly larger within the same dose range, but the follicular colloid area decreased to less than 60% control values at 12 mg/kg and remained at this size through 72 mg/kg. Maximum mobilization of T4 apparently occurred at 12 mg/kg and attenuated measured declines in circulating levels. Even though a large proportion of proven and probable estrogenic chlorobiphenyls (CBs) were present, the lower amounts of more potent antiestrogenic aryl hydrocarbon (Ah) receptor agonists and/or decreased responsiveness because of low serum T4 levels may have antagonized the uterotropic response.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzofurans,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Dichlorodiphenyl Dichloroethylene,
http://linkedlifedata.com/resource/pubmed/chemical/Insecticides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Polychlorinated Biphenyls,
http://linkedlifedata.com/resource/pubmed/chemical/Soil Pollutants,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrachlorodibenzodioxin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/chlorinated dibenzofurans
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0090-4341
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
334-43
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7487157-Adrenal Glands,
pubmed-meshheading:7487157-Animals,
pubmed-meshheading:7487157-Benzofurans,
pubmed-meshheading:7487157-Cytochrome P-450 CYP1A1,
pubmed-meshheading:7487157-Cytochrome P-450 CYP2B1,
pubmed-meshheading:7487157-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7487157-Dichlorodiphenyl Dichloroethylene,
pubmed-meshheading:7487157-Environmental Exposure,
pubmed-meshheading:7487157-Female,
pubmed-meshheading:7487157-Injections, Intraperitoneal,
pubmed-meshheading:7487157-Insecticides,
pubmed-meshheading:7487157-Kidney,
pubmed-meshheading:7487157-Microsomes, Liver,
pubmed-meshheading:7487157-Neutrophils,
pubmed-meshheading:7487157-Organ Size,
pubmed-meshheading:7487157-Oxidoreductases,
pubmed-meshheading:7487157-Polychlorinated Biphenyls,
pubmed-meshheading:7487157-Rats,
pubmed-meshheading:7487157-Rats, Sprague-Dawley,
pubmed-meshheading:7487157-Soil Pollutants,
pubmed-meshheading:7487157-Tetrachlorodibenzodioxin,
pubmed-meshheading:7487157-Thyroxine,
pubmed-meshheading:7487157-Tissue Distribution,
pubmed-meshheading:7487157-Uterus
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Environmental polychlorinated biphenyls: acute toxicity of landfill soil extract to female prepubertal rats.
|
| pubmed:affiliation |
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|