Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-12-21
|
| pubmed:abstractText |
Epinephrine commonly is added to epidural opioids and local anesthetics, however, little is known about the fate of epidurally administered epinephrine. Studies have identified the epinephrine metabolizing enzyme, catechol-O-methyl transferase (COMT), in the cranial meninges of several species. The purpose of this study was to determine whether the spinal meninges also contain COMT and are capable of metabolizing epinephrine. If so, then the spinal meninges may have an important impact in limiting the bioavailability of epinephrine in both the spinal cord and epidural space.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0003-3022
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1078-81
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7486158-Animals,
pubmed-meshheading:7486158-Catechol O-Methyltransferase,
pubmed-meshheading:7486158-Epinephrine,
pubmed-meshheading:7486158-Macaca nemestrina,
pubmed-meshheading:7486158-Meninges,
pubmed-meshheading:7486158-Metanephrine,
pubmed-meshheading:7486158-Species Specificity,
pubmed-meshheading:7486158-Spinal Cord,
pubmed-meshheading:7486158-Swine,
pubmed-meshheading:7486158-Sympathomimetics
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Epinephrine is metabolized by the spinal meninges of monkeys and pigs.
|
| pubmed:affiliation |
Department of Anesthesiology, University of Washington, Seattle 98195, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|