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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-12-28
|
| pubmed:abstractText |
Cytokine regulation was compared in three groups of Gabonese patients with Plasmodium falciparum malaria before and after therapy; adults with uncomplicated malaria, children with uncomplicated malaria, and children with severe malaria. Plasma levels of tumor necrosis factor (TNF), interleukin-6 (IL-6), IL-8, TNF receptors (TNF R), and the TNF/TNF R ratios were significantly higher in severe malaria compared with uncomplicated malaria. High plasma levels of all immunoregulatory molecules were associated with slow cure after therapy. In all patients, phytohemagglutinin-induced cytokine production was depressed on admission compared with convalescence. A significant difference was the higher TNF production capacity in patients with severe malaria on day 2 and day 5 compared with that in patients with uncomplicated malaria. In contrast to IL-6 and IL-8, a high TNF production capacity during the acute phase of malaria predicted a rapid clinical and parasitologic cure in the patients. These findings illustrate the dual role of TNF in the protection and pathology of malaria.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9637
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
532-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7485713-Adolescent,
pubmed-meshheading:7485713-Adult,
pubmed-meshheading:7485713-Child,
pubmed-meshheading:7485713-Child, Preschool,
pubmed-meshheading:7485713-Female,
pubmed-meshheading:7485713-Humans,
pubmed-meshheading:7485713-Infant,
pubmed-meshheading:7485713-Interleukin-6,
pubmed-meshheading:7485713-Interleukin-8,
pubmed-meshheading:7485713-Leukocytes,
pubmed-meshheading:7485713-Lymphocyte Activation,
pubmed-meshheading:7485713-Malaria, Falciparum,
pubmed-meshheading:7485713-Male,
pubmed-meshheading:7485713-Middle Aged,
pubmed-meshheading:7485713-Parasitemia,
pubmed-meshheading:7485713-Phytohemagglutinins,
pubmed-meshheading:7485713-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:7485713-Treatment Outcome,
pubmed-meshheading:7485713-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Prediction of accelerated cure in Plasmodium falciparum malaria by the elevated capacity of tumor necrosis factor production.
|
| pubmed:affiliation |
International Research Laboratory, Albert-Schweitzer-Hospital, Lamabarene, Gabon.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|