7485173

Source:http://linkedlifedata.com/resource/pubmed/id/7485173

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0796358, umls-concept:C1555775
pubmed:issue	5
pubmed:dateCreated	1995-11-30
pubmed:abstractText	We report the results of applying comparative genomic hybridization (CGH) in a cytogenetic service laboratory for (1) determination of the origin of extra and missing chromosomal material in intricate cases of unbalanced aberrations and (2) detection of common prenatal numerical chromosome aberrations. A total of 11 fetal samples were analyzed. Seven cases of complex unbalanced aberrations that could not be identified reliably by conventional cytogenetics were successfully resolved by CGH analysis. CGH results were validated by using FISH with chromosome-specific probes. Four cases representing common prenatal numerical aberrations (trisomy 21, 18, and 13 and monosomy X) were also successfully diagnosed by CGH. We conclude that CGH is a powerful adjunct to traditional cytogenetic techniques that makes it possible to solve clinical cases of intricate unbalanced aberrations in a single hybridization. CGH may also be a useful adjunct to screen for euchromatic involvement in marker chromosomes. Further technical development may render CGH applicable for routine aberration screening.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-1301994, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-1359641, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-1483693, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-2657708, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-2973607, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-3192212, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7522536, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7705181, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7705182, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7705184, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7743897, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7877949, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-7992835, http://linkedlifedata.com/resource/pubmed/commentcorrection/7485173-8444465
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0370475
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0002-9297
pubmed:author	pubmed-author:BryndorfTT, pubmed-author:ChristensenBB, pubmed-author:GerdesTT, pubmed-author:KallioniemiAA, pubmed-author:KirchhoffMM, pubmed-author:LEPEST JTJ, pubmed-author:LundsteenCC, pubmed-author:MaahrJJ, pubmed-author:PhilipJJ, pubmed-author:RoseHH
pubmed:issnType	Print
pubmed:volume	57
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1211-20
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:7485173-Chromosome Aberrations, pubmed-meshheading:7485173-Cytogenetics, pubmed-meshheading:7485173-Humans, pubmed-meshheading:7485173-In Situ Hybridization, Fluorescence, pubmed-meshheading:7485173-Karyotyping, pubmed-meshheading:7485173-Nucleic Acid Hybridization
pubmed:year	1995
pubmed:articleTitle	Comparative genomic hybridization in clinical cytogenetics.
pubmed:affiliation	Juliane Marie Center, Rigshospitalet, University of Copenhagen, Denmark.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't