Linked Life Data

7484207

Source:http://linkedlifedata.com/resource/pubmed/id/7484207

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1995-12-26
pubmed:abstractText
To assess the usefulness of Dy-DTPA-BMA-induced signal reduction, as an indicator of myocardial viability, myocardial infarction was induced in 17 domestic pigs by ligating a diagonal branch of the left anterior descending coronary artery (LAD). In 6 pigs, Dy-DTPA-BMA (1 mmol/kg b.w.) was administered 4 hours after induction of ischaemia. In 5 additional pigs, Gd-DTPA-BMA (0.3 mmol/kg b.w.) and Dy-DTPA-BMA (1 mmol/kg b.w.) were simultaneously injected after 4 hours of ischaemia to ascertain whether Dy-DTPA-BMA counteracted the signal enhancement effect of Gd-DTPA-BMA. A further 6 pigs with infarctions, not administered contrast medium, served as controls. All pigs were sacrificed after 6 hours of ischaemia, and the extirpated hearts were investigated with MR (ex vivo). The concentrations of Dy and Gd were determined in tissue samples from infarcted and non-ischaemic myocardium. The extracellular concentrations of both contrast media were monitored over time during 2 hours in the double-contrast group (in vivo), using a microdialysis technique and analysed by inductively coupled plasma atomic emission spectrometry (ICP-AES). The infarctions demonstrated a high SI in the proton density- and T2-weighted sequences, in both the Dy-DTPA-BMA and control groups, although the former group demonstrated a 3-fold greater concentration of Dy in infarcted compared with non-ischaemic myocardium. Dy-DTPA-BMA did not counteract the Gd-DTPA-BMA-induced enhancement of the infarcted tissue despite a 3-fold higher concentration. This lack of detectable susceptibility effects of Dy may be caused by a loss of cell membrane integrity in the infarcts, resulting in a homogeneous intra- and extracellular distribution of the contrast agent. This hypothesis of an expanded volume of distribution in infarcted tissue was further supported by the microdialysis data, demonstrating a similar extracellular concentration of contrast agents in infarcted and non-ischaemic myocardium, despite a proven 3-fold greater concentration in infarcted tissue samples. To investigate whether Gd-DTPA-BMA-enhanced MR imaging (ex vivo) permits differentiation between reperfused and non-reperfused myocardial infarction, and whether Dy-DTPA-BMA-enhanced MR imaging enables a differentiation between reversible and irreversible myocardial injury following reperfusion, myocardial infarction was induced in 24 domestic pigs (divided into 4 groups) by placing a patched ligature around a diagonal branch of the LAD. Four additional hearts were reperfused after 2 min of brief occlusion, not long enough to cause irreversible injury.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0365-5954
pubmed:author
pubmed:issnType
Print
pubmed:volume
397
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-44
pubmed:dateRevised
2008-4-9
pubmed:meshHeading
pubmed-meshheading:7484207-Analysis of Variance, pubmed-meshheading:7484207-Animals, pubmed-meshheading:7484207-Contrast Media, pubmed-meshheading:7484207-Diagnosis, Differential, pubmed-meshheading:7484207-Dysprosium, pubmed-meshheading:7484207-Evaluation Studies as Topic, pubmed-meshheading:7484207-Female, pubmed-meshheading:7484207-Gadolinium, pubmed-meshheading:7484207-Gadolinium DTPA, pubmed-meshheading:7484207-Magnetic Resonance Imaging, pubmed-meshheading:7484207-Male, pubmed-meshheading:7484207-Myocardial Infarction, pubmed-meshheading:7484207-Myocardial Ischemia, pubmed-meshheading:7484207-Myocardial Reperfusion, pubmed-meshheading:7484207-Myocardium, pubmed-meshheading:7484207-Organometallic Compounds, pubmed-meshheading:7484207-Pentetic Acid, pubmed-meshheading:7484207-Swine, pubmed-meshheading:7484207-Time Factors, pubmed-meshheading:7484207-Tissue Survival
pubmed:year
1995
pubmed:articleTitle
MR imaging of contrast-enhanced porcine myocardial infarction. Assessment of reperfusion and tissue viability.
pubmed:affiliation
Department of Diagnostic Radiology, Uppsala University Hospital, Sweden.
pubmed:publicationType
Journal Article, Comparative Study