Linked Life Data

7482536

Source:http://linkedlifedata.com/resource/pubmed/id/7482536

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-12-19
pubmed:abstractText
Selenium not only has an important role in controlling lipid hydroperoxides through glutathione peroxidase (GPX) activity, but also can produce oxidative stress through exposure to selenite. Because levels of lipid hydroperoxides affect the production of thromboxane A2 (TxA2) and prostacyclin (PGI2), selenium compounds may be able to influence the production of these two vasoactive substances. Late-gestation pregnancy reduces the half-life of PGI2; therefore, pregnancy itself may enhance susceptibility to changes in the production of TxA2 and PGI2. The objective of this investigation was to determine if different selenium compounds, selenite, selenate, and ebselen, can influence the human term placental production of thromboxane B2 (TxB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), the inactive hydrolysis products of TxA2 and PGI2. Although selenate exposure (40 microM 24 hr) increased TxB2 production, and ebselen (an organic selenium compound with GPX activity) exposure (40 microM, 24 hr) decreased both TxB2 and 6-keto-PGF1 alpha production, only selenite had a significant effect on the TxB2/6-keto-PGF1 alpha ratio. Three exposures to selenite at 6 microM (32 hr) significantly decreased 6-keto-PGF1 alpha production with no effect on TxB2 production or tissue GPX activity. Following two exposures to selenite at 20 and 40 microM (24 hr), TxB2 production was significantly increased, while tissue 6-keto-PGF1 alpha production and tissue GPX activity were significantly decreased. These results indicate that selenite, but not selenate or ebselen, can directly affect the human placenta by producing changes in the TxB2/6-keto-PGF1 alpha ratio, which may be related to increased vasoconstriction and blood coagulation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Azoles, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Chorionic Gonadotropin, http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase, http://linkedlifedata.com/resource/pubmed/chemical/Lactates, http://linkedlifedata.com/resource/pubmed/chemical/Organoselenium Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species, http://linkedlifedata.com/resource/pubmed/chemical/Selenium Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Sodium Selenite, http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane B2, http://linkedlifedata.com/resource/pubmed/chemical/ebselen, http://linkedlifedata.com/resource/pubmed/chemical/selenic acid
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The effect of selenium compounds (selenite, selenate, ebselen) on the production of thromboxane and prostacyclin by the human term placenta in vitro.
pubmed:affiliation
Department of Obstetrics and Gynecology, University of Rochester Medical Center, New York 14642-8668, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.