Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-12-4
|
| pubmed:abstractText |
The authors have investigated a panel of parameters for immunotoxicity that may be incorporated in routine screening for toxicity of pharmaceuticals. This panel comprises serum immunoglobulin concentrations, cellularity of bone marrow, weights and histopathology of thymus, spleen, and lymph nodes, histopathology of Peyers' patches, and FACScan analysis of lymphocyte subpopulations in the spleen, in addition to parameters of toxicity to other systems. To study the value of these assays for pharmaceuticals, the authors used the immunosuppressants azathioprine (AZP) and cyclosporin A (CsA) as model compounds with known immunotoxic activity. In two separate experiments, rats were treated by daily gastric intubation with 0, 5, 12.5, and 25 mg AZP/kg body wt or 0, 1.25, 5, and 20 mg CsA/kg body wt. In the AZP study, the histopathology of the thymus and the spleen were valuable parameters of immunotoxicity, since these organs showed microscopic alterations at relatively low dose levels. In the CsA experiment, both the histopathology of the thymus and the data provided by FACScan analysis were sensitive indicators of immunotoxicity detecting effects at the lowest dose level employed. The data indicate that the lymphoid system is the most sensitive target of toxicity after AZP or CsA administration. The authors conclude that their test battery yielded immunotoxicity profiles of AZP and CsA in rats that were consistent with published findings in the literature, indicating the usefulness of the test battery employed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0273-2300
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
327-38
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7480886-Administration, Oral,
pubmed-meshheading:7480886-Animals,
pubmed-meshheading:7480886-Azathioprine,
pubmed-meshheading:7480886-Blood Cell Count,
pubmed-meshheading:7480886-Body Weight,
pubmed-meshheading:7480886-Bone Marrow,
pubmed-meshheading:7480886-Bone Marrow Cells,
pubmed-meshheading:7480886-Cyclosporine,
pubmed-meshheading:7480886-Dose-Response Relationship, Drug,
pubmed-meshheading:7480886-Drug Administration Schedule,
pubmed-meshheading:7480886-Drug Evaluation, Preclinical,
pubmed-meshheading:7480886-Immunoglobulins,
pubmed-meshheading:7480886-Immunosuppressive Agents,
pubmed-meshheading:7480886-Lymphocyte Count,
pubmed-meshheading:7480886-Male,
pubmed-meshheading:7480886-Organ Size,
pubmed-meshheading:7480886-Organ Specificity,
pubmed-meshheading:7480886-Rats,
pubmed-meshheading:7480886-Rats, Wistar,
pubmed-meshheading:7480886-T-Lymphocyte Subsets
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Investigation of a screening battery for immunotoxicity of pharmaceuticals within a 28-day oral toxicity study using azathioprine and cyclosporin A as model compounds.
|
| pubmed:affiliation |
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|