|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1995-12-15
|
|
pubmed:abstractText |
34 patients with locally advanced (T4) or recurrent rectal cancer have been treated with: 1. external beam radiotherapy (45-48 Gy) + 5FU(1000 mg/m2/daily iv continuous infusion day 1-4) + MMC (10 mg/m2/daily iv, day 1); 2. surgical resection (if feasible) + IORT (10-15 Gy); 3. adjuvant chemotherapy (5FU+leucovorin, 6-8 cycles). Grade 3 acute hematological toxicity was observed in 1 case only. 23 of 34 patients underwent radical surgery. Perioperative mortality and morbidity was 0% and 17% respectively. In the 23 operated patients with a mean follow-up of 18.6 months there were 2 local recurrences, 5 blood metastases, (1 death of disease). 16 patients were shown to be NED (3-36 months).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0390-7740
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
197-207
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:7480868-Antibiotics, Antineoplastic,
pubmed-meshheading:7480868-Antidotes,
pubmed-meshheading:7480868-Antimetabolites, Antineoplastic,
pubmed-meshheading:7480868-Chemotherapy, Adjuvant,
pubmed-meshheading:7480868-Combined Modality Therapy,
pubmed-meshheading:7480868-Fluorouracil,
pubmed-meshheading:7480868-Follow-Up Studies,
pubmed-meshheading:7480868-Humans,
pubmed-meshheading:7480868-Leucovorin,
pubmed-meshheading:7480868-Lymph Node Excision,
pubmed-meshheading:7480868-Mitomycin,
pubmed-meshheading:7480868-Neoplasm Recurrence, Local,
pubmed-meshheading:7480868-Postoperative Care,
pubmed-meshheading:7480868-Preoperative Care,
pubmed-meshheading:7480868-Radiotherapy Dosage,
pubmed-meshheading:7480868-Rectal Neoplasms,
pubmed-meshheading:7480868-Time Factors
|
|
pubmed:articleTitle |
Preoperative concomitant radiochemotherapy and IORT in locally advanced rectal cancer.
|
|
pubmed:affiliation |
Istituto di Clinica Chirurgica Generale, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Roma, Italy.
|
|
pubmed:publicationType |
Journal Article
|
