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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1995-12-28
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pubmed:abstractText |
Another class of growth hormone (GH) secretagogues has been discovered by altering the backbone structure of a flexible linear GH-releasing peptide (GHRP). In vitro and in vivo characterization confirms these GH secretagogues as the most potent and smallest (M(r) < 500) reported. Anabolic efficacy is demonstrated in rodents with intermittent delivery. A convergent model of the bioactive conformation of GHRPs is developed and is supported by the NMR structure of a highly potent cyclic analog of GHRP-2. The model and functional data provide a logical framework for the further design of low-molecular weight secretagogues and illustrate the utility of an interdisciplinary approach to elucidating potential bound-state conformations of flexible peptide ligands.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-1346381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-1674284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-2004615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-2108187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-2541999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-4029086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-6109621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-6313936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-6425039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-6714155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-8095015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-8374685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479958-8503009
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:BurdickD JDJ,
pubmed-author:BurnierJ PJP,
pubmed-author:ClarkR GRG,
pubmed-author:EliasK AKA,
pubmed-author:FUNK,
pubmed-author:FairbrotherW JWJ,
pubmed-author:HammondsR GRG,
pubmed-author:IngleG SGS,
pubmed-author:JacobsenN ENE,
pubmed-author:LAIS HSH,
pubmed-author:McDowellR SRS,
pubmed-author:MortensenD LDL,
pubmed-author:RawsonT ETE,
pubmed-author:SomersT CTC,
pubmed-author:StanleyM SMS
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11165-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7479958-Amino Acid Sequence,
pubmed-meshheading:7479958-Animals,
pubmed-meshheading:7479958-Consensus Sequence,
pubmed-meshheading:7479958-Female,
pubmed-meshheading:7479958-Growth Hormone,
pubmed-meshheading:7479958-Hormones,
pubmed-meshheading:7479958-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7479958-Models, Molecular,
pubmed-meshheading:7479958-Molecular Sequence Data,
pubmed-meshheading:7479958-Oligopeptides,
pubmed-meshheading:7479958-Peptides, Cyclic,
pubmed-meshheading:7479958-Pituitary Gland, Anterior,
pubmed-meshheading:7479958-Protein Structure, Secondary,
pubmed-meshheading:7479958-Rats,
pubmed-meshheading:7479958-Rats, Sprague-Dawley,
pubmed-meshheading:7479958-Secretory Rate,
pubmed-meshheading:7479958-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.
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pubmed:affiliation |
Department of Bioorganic Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
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pubmed:publicationType |
Journal Article
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