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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1995-12-21
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pubmed:abstractText |
The crystal structure of the decanucleotide d(CGCAATTGCG)2 has been solved by a combination of molecular replacement and heavy-atom procedures and has been refined to an R factor of 20.2% at 2.7 A. It is not a fully base-paired duplex but has a central core of eight Watson-Crick base pairs flanked by unpaired terminal guanosines and cytosines. These participate in hydrogen-bonding arrangements with adjacent decamer duplexes in the crystal lattice. The unpaired guanosines are bound in the G+C regions of duplex minor grooves. The cytosines have relatively high mobility, even though they are constrained to be in one region where they are involved in base-paired triplets with G.C base pairs. The 5'-AATT sequence in the duplex region has a narrow minor groove, providing further confirmation of the sequence-dependent nature of groove width.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1406328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1510987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1593626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1593627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1643044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1758883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-17810339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1850624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-1988677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-2021634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-2299669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-2991536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-3897553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-6273591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7515488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7522550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7684365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7939719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7966274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-7979259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8170950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8196049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8196053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8293469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8395202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8462093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479880-8510155
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10767-71
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:7479880-Base Composition,
pubmed-meshheading:7479880-Base Sequence,
pubmed-meshheading:7479880-Crystallography, X-Ray,
pubmed-meshheading:7479880-DNA,
pubmed-meshheading:7479880-G-Quadruplexes,
pubmed-meshheading:7479880-Hydrogen Bonding,
pubmed-meshheading:7479880-Models, Molecular,
pubmed-meshheading:7479880-Molecular Sequence Data,
pubmed-meshheading:7479880-Nucleic Acid Conformation,
pubmed-meshheading:7479880-Oligodeoxyribonucleotides
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pubmed:year |
1995
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pubmed:articleTitle |
Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction.
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pubmed:affiliation |
Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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