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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1995-11-30
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pubmed:abstractText |
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic excitation]: transformation of GABA-mediated synaptic inhibition into synaptic excitation. This transformation persists with no further paired stimulation for 60 min or longer and is termed long-term transformation. Long-term transformation is shown to contribute to pairing-induced long-term potentiation but not to long-term potentiation induced by presynaptic stimulation alone. Further support for such mechanistic divergence is provided by pharmacologic effects on long-term transformation as well as these two forms of long-term potentiation by Cl- channel blockers, glutamate and GABA antagonists, as well as the endogenous cannabinoid ligand anandamide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1315042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1330058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1334550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-13751136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1470919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1684989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-1847993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-2167975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-2308954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-2424084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-2465608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-2566657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-551280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-6259733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-7143035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-7509523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8022836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8119321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8159242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8159706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8382497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8389828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8395053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7479747-8421494
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10167-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7479747-Animals,
pubmed-meshheading:7479747-Arachidonic Acids,
pubmed-meshheading:7479747-Baclofen,
pubmed-meshheading:7479747-Calcium Channel Blockers,
pubmed-meshheading:7479747-Chloride Channels,
pubmed-meshheading:7479747-Furosemide,
pubmed-meshheading:7479747-Hippocampus,
pubmed-meshheading:7479747-Long-Term Potentiation,
pubmed-meshheading:7479747-Male,
pubmed-meshheading:7479747-Models, Neurological,
pubmed-meshheading:7479747-Polyunsaturated Alkamides,
pubmed-meshheading:7479747-Pyramidal Cells,
pubmed-meshheading:7479747-Rats,
pubmed-meshheading:7479747-Rats, Sprague-Dawley,
pubmed-meshheading:7479747-Snails,
pubmed-meshheading:7479747-Synapses,
pubmed-meshheading:7479747-Synaptic Transmission,
pubmed-meshheading:7479747-gamma-Aminobutyric Acid
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pubmed:year |
1995
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pubmed:articleTitle |
Long-term synaptic transformation of hippocampal CA1 gamma-aminobutyric acid synapses and the effect of anandamide.
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pubmed:affiliation |
Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
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