| pubmed-article:7478556 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7478556 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7478556 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7478556 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:7478556 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7478556 | pubmed:dateCreated | 1995-11-28 | lld:pubmed |
| pubmed-article:7478556 | pubmed:abstractText | FDC-P1 haemopoietic cells were used to select mutations of c-fms that constitutively activate the receptor for macrophage-colony stimulating factor (M-CSF or CSF-1). One mutation changed Ser 929 to Gly within a Ser/Gly rich region of the C-terminal tail and a second changed a nearby, highly conserved Leu 926 for Pro. A third mutation (D802V) changed Asp 802 to Val within the alpha L12/beta 9 region of the tyrosine kinase domain, so supporting the crystallographic evidence that this region triggers kinase activation. A c-kit mutation exactly equivalent to D802V was previously identified in a leukamic cell line and was demonstrated here to be transforming. Surprisingly, although D802V potently transformed FDC-P1 cells, it could not induce Rat-2 fibroblast foci, even in the presence of M-CSF. It is suggested that the accelerated receptor degradation induced by D802V may account for its cell specific effect. | lld:pubmed |
| pubmed-article:7478556 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7478556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7478556 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7478556 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7478556 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:7478556 | pubmed:author | pubmed-author:BakerD ADA | lld:pubmed |
| pubmed-article:7478556 | pubmed:author | pubmed-author:CelettiAA | lld:pubmed |
| pubmed-article:7478556 | pubmed:author | pubmed-author:DibbN JNJ | lld:pubmed |
| pubmed-article:7478556 | pubmed:author | pubmed-author:GloverH RHR | lld:pubmed |
| pubmed-article:7478556 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7478556 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:7478556 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:7478556 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7478556 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7478556 | pubmed:pagination | 1347-56 | lld:pubmed |
| pubmed-article:7478556 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7478556 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7478556 | pubmed:articleTitle | Selection of activating mutations of c-fms in FDC-P1 cells. | lld:pubmed |
| pubmed-article:7478556 | pubmed:affiliation | Department of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, London. | lld:pubmed |
| pubmed-article:7478556 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7478556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7478556 | lld:pubmed |
