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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
The effects of adrenal steroids on synaptic plasticity were investigated in the dentate gyrus of the hippocampus. Experiments were performed in either adrenalectomized or intact (non-adrenalectomized), anesthetized rats. High-frequency stimulation was applied to the medial perforant pathway at three different frequencies; 100, 200 or 400 Hz, either post- or pre- and post-administration of the specific Type-II adrenal steroid receptor agonist RU 28362. High-frequency stimulation prior to RU 28362 administration produced a frequency-dependent long-term potentiation of the population spike, with 100 Hz showing no long-term potentiation and 400 Hz the highest degree of potentiation. In contrast, following administration of RU 28362, high-frequency stimulation produced a long-term depression (in comparison to baseline). In the experiments in which high-frequency stimulation was applied both pre- and post-RU 28362 administration, the size of the population spike was initially potentiated and then depotentiated after the RU 28362 injection. This effect was also frequency dependent, although opposite to the long-term potentiation effect. That is, 400 Hz was the least effective frequency for inducing long-term depression/depotentiation, while 100 Hz was the most effective. Long-term depression/depotentiation was immediate following high-frequency stimulation and lasted for the extent of the recording session, in some cases longer than 1 h. Similar to the finding reported in the accompanying paper, induction of long-term potentiation was substantially suppressed by RU 28362. However, in a number of experiments long-term potentiation could still be induced after RU 28362 administration, even after long-term depression/depotentiation had been established. In these cases, stimulation at the higher frequencies was necessary.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/11,17-dihydroxy-6-methyl-17-(1-propy...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenal Cortex Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Androstanols,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0306-4522
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
379-85
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7477947-Adrenal Cortex Hormones,
pubmed-meshheading:7477947-Androstanols,
pubmed-meshheading:7477947-Animals,
pubmed-meshheading:7477947-Corticosterone,
pubmed-meshheading:7477947-Dentate Gyrus,
pubmed-meshheading:7477947-Depression, Chemical,
pubmed-meshheading:7477947-Electric Stimulation,
pubmed-meshheading:7477947-Electrophysiology,
pubmed-meshheading:7477947-Evoked Potentials,
pubmed-meshheading:7477947-Hippocampus,
pubmed-meshheading:7477947-Injections,
pubmed-meshheading:7477947-Male,
pubmed-meshheading:7477947-Neuronal Plasticity,
pubmed-meshheading:7477947-Rats,
pubmed-meshheading:7477947-Rats, Sprague-Dawley,
pubmed-meshheading:7477947-Receptors, Steroid,
pubmed-meshheading:7477947-Synapses
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pubmed:year |
1995
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pubmed:articleTitle |
Hippocampal homosynaptic long-term depression/depotentiation induced by adrenal steroids.
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pubmed:affiliation |
Rockefeller University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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