Linked Life Data

7477926

Source:http://linkedlifedata.com/resource/pubmed/id/7477926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-11-30
pubmed:abstractText
The ventral forebrain, including the ventral striatum, the ventral pallidum and the substantia innominata, is an important region involved in the functions of the basal ganglia and the limbic system, as well as the magnocellular corticopetal neurons of the nucleus basalis of Meynert. Although previous studies have shown that this region is richly innervated by GABAergic fibers, little is known with respect to the relative densities of GABAergic to non-GABAergic axon terminals in this region. To address this issue, we have developed a specific rabbit antiserum to GABA and used a postembedding immunocytochemical reaction to analyse the distribution of GABA-like immunoreactive axon terminals in the rat ventral striatum, ventral pallidum and substantia innominata. Of all axon terminals that form identifiable synapses within single ultrathin sections taken from these regions, 11.6% in the ventral striatum, 85.5% in the ventral pallidum and 64.8% in the substantia innominata were GABAergic. Differences were also found in the distribution patterns of these terminals with respect to the size of their synaptic target dendrites. These findings are consistent with previous findings that a majority of inputs to the ventral striatum are excitatory, and that a majority of inputs to the ventral pallidum are inhibitory. Our results provide a first approximation of the anatomical substrate for the physiology and pharmacology of GABA actions in the ventral forebrain region. These results also show that GABA may play an important role in the substantia innominata, where both the cholinergic and the non-cholinergic magnocellular corticopetal neurons reside within a neuropil innervated by many different non-cholinergic fibers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
GABAergic axons in the ventral forebrain of the rat: an electron microscopic study.
pubmed:affiliation
Department of Anatomy & Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't