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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-12-4
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pubmed:abstractText |
The induction of the early-gene c-fos after administration of the adenosine A2a receptor agonist CGS 21680, was studied in the striatum of normal rats or in rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigrostriatal neurons. CGS 21680 (2.25 mg/kg) induces c-fos expression in the 6-hydroxydopamine-lesioned striatum, while up to 40 mg/kg fails to induce c-fos in the intact striatum or in the striatum of normal rats. Blockade of muscarine receptors by scopolamine (5 mg/kg) partially prevents, and stimulation of dopamine D2 receptors by quinpirole (0.5 mg/kg) completely reverses, CGS 21680-induced c-fos expression in the 6-hydroxydopamine-lesioned striatum. In turn, CGS 21680 partially reverses c-fos expression induced by quinpirole in the lesioned globus pallidus. CGS 21680, in addition, dose-dependently reduces the turning behavior induced by quinpirole (0.5 mg/kg) in 6-hydroxydopamine-lesioned rats. The results suggest that CGS 21680 induces c-fos expression in the striatum through direct and indirect mechanisms related to the ability of A2a receptors to stimulate cyclic AMP formation or acetylcholine release which in turn would activate c-fos through muscarinic receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-(2-carboxyethyl)phenethylamino)...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenethylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P1 Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0306-4522
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:geneSymbol |
c-fos
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-55
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7477908-Adenosine,
pubmed-meshheading:7477908-Animals,
pubmed-meshheading:7477908-Antihypertensive Agents,
pubmed-meshheading:7477908-Ergolines,
pubmed-meshheading:7477908-Gene Expression,
pubmed-meshheading:7477908-Genes, fos,
pubmed-meshheading:7477908-Immunohistochemistry,
pubmed-meshheading:7477908-Male,
pubmed-meshheading:7477908-Muscarinic Antagonists,
pubmed-meshheading:7477908-Neostriatum,
pubmed-meshheading:7477908-Neurons,
pubmed-meshheading:7477908-Oxidopamine,
pubmed-meshheading:7477908-Phenethylamines,
pubmed-meshheading:7477908-Purinergic P1 Receptor Agonists,
pubmed-meshheading:7477908-Quinpirole,
pubmed-meshheading:7477908-Rats,
pubmed-meshheading:7477908-Rats, Sprague-Dawley,
pubmed-meshheading:7477908-Receptors, Dopamine D2,
pubmed-meshheading:7477908-Receptors, Purinergic P1,
pubmed-meshheading:7477908-Stereotyped Behavior,
pubmed-meshheading:7477908-Sympathectomy, Chemical
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pubmed:year |
1995
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pubmed:articleTitle |
Adenosine A2 receptors stimulate c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats.
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pubmed:affiliation |
Department of Toxicology, University of Calgliari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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