| pubmed-article:7477409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C2003939 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C0205122 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7477409 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7477409 | pubmed:issue | 6556 | lld:pubmed |
| pubmed-article:7477409 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7477409 | pubmed:abstractText | The mixed-lineage leukaemia gene (MLL/HRX/ALL-1) is disrupted by chromosomal translocation in human acute leukaemias that often display mixed lymphoid-myeloid phenotypes and present in infancy. MLL possesses a highly conserved SET domain also found in Drosophila trithorax (trx) and Polycomb group (Pc-G) genes, which are known to regulate homeotic genes (HOM-C) in a positive or negative fashion, respectively. Mll was targeted in mice by homologous recombination in embryonic stem (ES) cells to assess its role in pattern development. Mll heterozygous (+/-) mice had retarded growth, displayed haematopoietic abnormalities, and demonstrated bidirectional homeotic transformations of the axial skeleton as well as sternal malformations. Mll deficiency (-/-) was embryonic lethal. Anterior boundaries of Hoxa-7 and Hoxc-9 expression were shifted posteriorly in Mll +/- embryos, but their expression was abolished in Mll -/- embryos. Thus Mll is required for proper segment identity in mammals, displays haplo-insufficiency, and positively regulates Hox gene expression. | lld:pubmed |
| pubmed-article:7477409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7477409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7477409 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7477409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7477409 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7477409 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7477409 | pubmed:author | pubmed-author:BrownG AGA | lld:pubmed |
| pubmed-article:7477409 | pubmed:author | pubmed-author:HessJ LJL | lld:pubmed |
| pubmed-article:7477409 | pubmed:author | pubmed-author:KorsmeyerS... | lld:pubmed |
| pubmed-article:7477409 | pubmed:author | pubmed-author:YuB DBD | lld:pubmed |
| pubmed-article:7477409 | pubmed:author | pubmed-author:HorningS ESE | lld:pubmed |
| pubmed-article:7477409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7477409 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:7477409 | pubmed:volume | 378 | lld:pubmed |
| pubmed-article:7477409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7477409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7477409 | pubmed:pagination | 505-8 | lld:pubmed |
| pubmed-article:7477409 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7477409 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7477409 | pubmed:articleTitle | Altered Hox expression and segmental identity in Mll-mutant mice. | lld:pubmed |
| pubmed-article:7477409 | pubmed:affiliation | Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA. | lld:pubmed |
| pubmed-article:7477409 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7477409 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7477409 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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