Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6556
|
| pubmed:dateCreated |
1995-12-28
|
| pubmed:abstractText |
The mixed-lineage leukaemia gene (MLL/HRX/ALL-1) is disrupted by chromosomal translocation in human acute leukaemias that often display mixed lymphoid-myeloid phenotypes and present in infancy. MLL possesses a highly conserved SET domain also found in Drosophila trithorax (trx) and Polycomb group (Pc-G) genes, which are known to regulate homeotic genes (HOM-C) in a positive or negative fashion, respectively. Mll was targeted in mice by homologous recombination in embryonic stem (ES) cells to assess its role in pattern development. Mll heterozygous (+/-) mice had retarded growth, displayed haematopoietic abnormalities, and demonstrated bidirectional homeotic transformations of the axial skeleton as well as sternal malformations. Mll deficiency (-/-) was embryonic lethal. Anterior boundaries of Hoxa-7 and Hoxc-9 expression were shifted posteriorly in Mll +/- embryos, but their expression was abolished in Mll -/- embryos. Thus Mll is required for proper segment identity in mammals, displays haplo-insufficiency, and positively regulates Hox gene expression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mll protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
378
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
505-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7477409-Animals,
pubmed-meshheading:7477409-Cell Line,
pubmed-meshheading:7477409-Chimera,
pubmed-meshheading:7477409-DNA-Binding Proteins,
pubmed-meshheading:7477409-Embryonic and Fetal Development,
pubmed-meshheading:7477409-Female,
pubmed-meshheading:7477409-Fetus,
pubmed-meshheading:7477409-Gene Expression Regulation, Developmental,
pubmed-meshheading:7477409-Gene Targeting,
pubmed-meshheading:7477409-Genes, Homeobox,
pubmed-meshheading:7477409-Heterozygote,
pubmed-meshheading:7477409-Homozygote,
pubmed-meshheading:7477409-Humans,
pubmed-meshheading:7477409-Male,
pubmed-meshheading:7477409-Mice,
pubmed-meshheading:7477409-Mutagenesis,
pubmed-meshheading:7477409-Mutation,
pubmed-meshheading:7477409-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:7477409-Proto-Oncogenes,
pubmed-meshheading:7477409-Transcription Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Altered Hox expression and segmental identity in Mll-mutant mice.
|
| pubmed:affiliation |
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|